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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anti-inflammatory effects of monoterpenoids in rats with TNBS-induced colitis

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Author(s):
Alexandrino, Thais Dolfini [1] ; Tomazini Munhoz Moya, Amanda Maria [1] ; Madureira de Medeiros, Tiago Daniel [1] ; Morari, Joseane [2] ; Velloso, Licio Augusto [2] ; Leal, Raquel Franco [2] ; Marostica, Mario Roberto [1] ; Pastore, Glaucia Maria [1] ; Betim Cazarin, Cinthia Bau [1] ; Bicas, Juliano Lemos [1]
Total Authors: 10
Affiliation:
[1] Univ Estadual Campinas, Sch Food Engn, Rua Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Rua Tessalia Vieira Camargo 126, BR-13083887 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PHARMANUTRITION; v. 14, DEC 2020.
Web of Science Citations: 0
Abstract

Background: Ulcerative colitis is an idiopathic disease, characterized by an inflammation of the intestinal mucosa. Considering that the dietary pattern can be related to both its occurrence and its protection, studies with food terpenoids have been conducted, indicating that such compounds present an anti-inflammatory effect in experimental models. Methods: The present study evaluated the effect of AIN-93 G diets supplemented (1470 mg/kg) with different enantiomers (R-(+)and S-(-)-) of alpha-terpineol and limonene-1,2-diol on TNBS-induced colitis in male Wistar rats. The colon was analyzed in terms of: assessment of tissue damage, levels of cytokines, antioxidant status, besides gene expression of tight junction proteins, proand anti-inflammatory cytokines. Results: Anti-inflammatory effect was observed, since monoterpenoid consumption reduced the TNF-alpha levels up to five times, in most groups. Moreover, supplemented diets, particularly with S-(-)-alpha-terpineol and limonene1,2-diol, promoted a significant increase in gene expression of the anti-inflammatory cytokine IL-10. Conclusions: In general, no significant differences were observed between the effects of alpha-terpineol enantiomers. The results described in this article encourage future studies on the use of monoterpenoids to help treat colitis and inflammatory diseases. (AU)

FAPESP's process: 16/21619-7 - Evaluation of the biological properties of limonene biotransformation products
Grantee:Juliano Lemos Bicas
Support Opportunities: Regular Research Grants
FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
Grantee:Glaucia Maria Pastore
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
Grantee:Mário Roberto Maróstica Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
Grantee:Mário Roberto Maróstica Junior
Support Opportunities: Regular Research Grants