One of the main trends for obtaining aroma compounds is based on the microbial biotransformation of terpenes, a method capable of selectively generating substances considered "natural". This fact results in a large industrial interest in these bioprocesses. Brazil has high availability of terpene substrates at low prices, and, in recent years, this country has become internationally prominent in the scientific and academic development in this area. The growing research on the biological potential of limonene, major component of oil of orange peel, and its derivatives has increased the interest in such products. Therefore, this project aims to study the biological effect of limonene biotransformation products, whose production processes are well established in our research group, particularly for the enantiomers [R - (+) and S - (-)] of ± -terpineol and limonene-1,2-diol. After being produced, such compounds will be evaluated for their potential anti-proliferative in tumor cell lines, as well as their effect on experimental model of intestinal inflammation induction. The main expected results are: i) the discovery of new biological properties derived from the biotransformation of limonene, particularly limonene-1,2-diol, for which no biological property has been previously reported; ii) the identification of possible differences in terms of biological activity for enantiomers of ±-terpineol; iii) studies on the anti-inflammatory activity of monoterpenes and (iv) strengthening of collaborative networks of researchers in this area. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
PAULINO, BRUNO NICOLAU;
PASTORE, GLAUCIA MARIA;
BICAS, JULIANO LEMOS.
Biogeneration of aroma compounds.
CURRENT OPINION IN FOOD SCIENCE,
Web of Science Citations: 5.
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