Obtaining pectin nanofibers applied to the modify release of hydroxychloroquine

• Grant number: 17/20006-4
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2018
• End date: April 30, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Kelly Roberta Francisco Muruci de Paula
• Grantee: Kelly Roberta Francisco Muruci de Paula
• Host Institution: Centro de Ciências Agrárias (CCA). Universidade Federal de São Carlos (UFSCAR). Araras , SP, Brazil
• Associated researchers: Osvaldo de Freitas

Abstract

The understanding of the self-aggregation process as well as the dynamics of colloidal particles in interfaces are important in several biological, industrial and technological processes. In this way, the use of electric fields is strategically important in obtaining materials highly organized and oriented, which can be used in several technological sectors, especially those materials that present high interfacial area, since they can be used as vehicles for controlled release of active molecules in a more selective and efficient way.This project has the aim of developing a research group at the UFSCar campus Araras, where the applicant was recently hired as a Professor, focused on the understanding of surface phenomena and to obtain self-organized structures due to the application of electric fields, namely, obtaining pectin nanofibers by electrospinning to be used as carriers of the hydroxychloroquine. It is proposed the use of electron microscopy and atomic force, thermal measurements, as well as chemical composition characterization techniques (such as infrared spectroscopy and X-ray diffraction) for the analysis of new biomaterials. The results should contribute to understanding interfacial phenomena of self-organizing systems as well as obtaining micro and nanostructured materials by applying electric fields. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TANGANINI, ISABELLA C.; SHIRAHIGUE, LIGIANNE D.; DA SILVA, MARIANA ALTENHOFEN; FRANCISCO, KELLY R.; CECCATO-ANTONINI, SANDRA R.. Bioprocessing of shrimp wastes to obtain chitosan and its antimicrobial potential in the context of ethanolic fermentation against bacterial contamination. 3 BIOTECH, v. 10, n. 3, FEB 24 2020. (17/20006-4, 14/17794-2, 18/19139-2)

TANGANINI, ISABELLA C.; SHIRAHIGUE, LIGIANNE D.; DA SILVA, MARIANA ALTENHOFEN; FRANCISCO, KELLY R.; CECCATO-ANTONINI, SANDRA R.. Bioprocessing of shrimp wastes to obtain chitosan and its antimicrobial potential in the context of ethanolic fermentation against bacterial contamination. 3 BIOTECH, v. 10, n. 3, p. 9-pg., 2020-02-24. (14/17794-2, 17/20006-4, 18/19139-2)

NASCIMENTO, JONATAS U.; ZAMBUZI, GIOVANA C.; FERREIRA, JOAO O.; PAULA, JULIA H.; RIBEIRO, TATIANA S.; SOUZA, ADRIANO L.; DREISS, CECILE A.; SILVA, LUCIMARA L.; FRANCISCO, KELLY R.. A simple process to tune wettability of pectin-modified silanized glass. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 577, p. 67-74, SEP 20 2019. (17/20006-4, 18/12146-3, 15/24136-4, 16/21616-8)

VICTÓRIA DE OLIVEIRA MARGARIDO; JULIA HELENA DE PAULA; KELLY ROBERTA FRANCISCO; ADRIANO LOPES DE SOUZA. Atividade eletrocatalítica de um filme de ormosil híbrido contendo ácido fosfomolíbdico para o herbicida prometon. MATERIA-RIO DE JANEIRO, v. 25, n. 4, 2020-12-11. (17/20006-4, 16/21616-8, 18/05200-1, 15/24136-4)

ULRICH, GABRIELLA D.; LEMOS, ANA G.; SILVA-ALVAREZ, AMANDA C. F.; PAIVA, LUCILENE B.; GAVIOLI, RENATO R.; DA SILVA, LUCIMARA L.; DE FREITAS, OSVALDO; FRANCISCO, KELLY R.. Zein/hydroxypropylcellulose biofilms with hydrophilic and hydrophobic montmorillonite clays. Polymer Composites, v. N/A, p. 11-pg., 2023-02-01. (17/20006-4)

ZAMBUZI, GIOVANA C.; CAMARGOS, CAMILLA H. M.; FERREIRA, MAIRA P.; REZENDE, CAMILA A.; DE FREITAS, OSVALDO; FRANCISCO, KELLY R.. Modulating the controlled release of hydroxychloroquine mobilized on pectin films through film-forming pH and incorporation of nanocellulose. CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS, v. 2, p. 11-pg., 2021-12-25. (18/23769-1, 18/12146-3, 17/20006-4)