Modified release mechanisms study of hydroxychloroquine mobilized in pectin

• Grant number: 18/12146-3
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2018
• Effective date (End): November 30, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Kelly Roberta Francisco Muruci de Paula
• Grantee: Giovana Cristina Zambuzi
• Home Institution: Centro de Ciências Agrárias (CCA). Universidade Federal de São Carlos (UFSCAR). Araras , SP, Brazil

Abstract

This project inserts within the development of new materials focused on self-assembled structures obtained from biopolymers, which are strategic for the controlled release of substances used in various industrial and technological sectors. In this context, thin films of pectin obtained by casting at different pH values will be used to carry the hydroxychloroquine molecule. It is proposed the use of scanning electron microscopy, as well as the chemical composition characterization (infrared, X-ray dispersive energy and X-ray diffraction). In addition, the thermal behavior of the films and the release profile of hydroxychloroquine will be analyzed to better understand the intra and intermolecular interactions established between the macromolecule and the drug. The results should contribute to understand the phenomena involved in the modified release of hydroxychloroquine mobilized in pectin, in which the mechanisms of drug release will be evaluated from kinetic models. This work is part of a larger general project supported by FAPESP (Process: 2017/20006-4).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NASCIMENTO, JONATAS U.; ZAMBUZI, GIOVANA C.; FERREIRA, JOAO O.; PAULA, JULIA H.; RIBEIRO, TATIANA S.; SOUZA, ADRIANO L.; DREISS, CECILE A.; SILVA, LUCIMARA L.; FRANCISCO, KELLY R. A simple process to tune wettability of pectin-modified silanized glass. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 577, p. 67-74, SEP 20 2019. Web of Science Citations: 0.