Fetal deaths: challenges for knowledge and intervention

• Grant number: 16/07765-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: May 01, 2018
• End date: October 31, 2025
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Nelson da Cruz Gouveia
• Grantee: Nelson da Cruz Gouveia
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Hillegonda Maria Dutilh Novaes ; Marcia Furquim de Almeida ; Rossana Pulcineli Vieira Francisco
• Associated researchers: Andrés Jimenez Galisteo Jr ; Clarisse Martins Machado ; Expedito José de Albuquerque Luna ; Gerusa Maria Figueiredo ; Gizelton Pereira Alencar ; Heitor Franco de Andrade Junior ; Laura Cunha Rodrigues ; Luciana Regina Meireles Jaguaribe Ekman ; Mara Sandra Hoshida ; Maria Cristina Domingues da Silva Fink ; Paulo Hilário Nascimento Saldiva ; Zilda Pereira da Silva
• Associated research grant(s): 18/11756-2 - Multi-user equipment approved in grant 2016/07765-0: QUANTSTUDIO 6 Flex Real-Time PCR System, AP.EMU
• Associated scholarship(s): 23/17594-2 - Application of machine learning methods to perform mediation analyzes and interaction analyzes in the study of fetal mortality, BP.PD; 23/16599-0 - Completeness of Prenatal Cards and agreement between the data recorded on the cards and in interviews with parturient women, BP.IC; 23/02923-0 - Impact of parasitic and bacterial infections on fetal mortality, BP.TT; + associated scholarships 22/16153-0 - Air pollution and fetal deaths, BP.PD; 23/00150-4 - Analysis of social support networks in situations of fetal loss, BP.IC; 22/13271-1 - Factors associated with fetal vulnerability and to fetal death, BP.PD; 22/08921-7 - Evaluation of viral infection in fetal mortality: Detection of viral RNA/DNA and IgM/IgG antibodies., BP.TT; 22/05459-0 - Impact of parasitic and bacterial infections on fetal mortality, BP.TT; 21/06261-7 - Analysis of the quality of filling prenatal cards, in a case control study on fetal mortality, in the city of São Paulo, BP.IC; 20/13005-4 - Role of viral infections in fetal mortality, BP.TT; 20/05458-9 - Prenatal and obstetric care public policies and fetal death, BP.PD; 20/03557-0 - Role of viral infections in fetal mortality, BP.TT; 19/21876-8 - Role of viral infections in fetal mortality, BP.TT; 19/09533-8 - Analysis of the scales to measure perinatal grief, BP.TT; 18/19592-9 - Fetal death: analysis of angiogenic and anti-angiogenic factors and minimally invasive autopsy, BP.PD - associated scholarships

Abstract

Although fetal mortality is an increasingly important component of mortality in childhood, it is still insufficiently known, valued and studied as a public health problem, especially through approaches that integrate the biological, epidemiological and social dimensions. The proposed project aims to contribute to decreasing fetal mortality by increasing understanding of the complex network of causation and needs related to fetal death, using a multidisciplinary approach, to produce evidence to inform the development of public policies and clinical protocols for antenatal care and delivery care that incorporate prevention of fetal deaths and adequate support to bereaved families. We propose a prospective case control study with 415 cases (stillbirths) e 415 controls (randomly selected liveborns) ascertained in 15 SUS hospitals (which include a high proportion of all fetal deaths in the city of Sao Paulo). Mothers of cases and controls will be interviewed in the maternity hospitals, hospital records reviewed and information abstracted in a standard form, ante natal care card photographed; blood will be collected from mothers of cases and controls, cord blood collected from controls, and placenta stored for investigation of serum and tissue markers of angiogenesis, markers of infection and exposure to air pollutants. Non invasive autopsy will be conducted in all stillbirths, by imaging and histopathology guided by image as well as traditional autopsy. Administrators of hospitals and the antenatal care program Rede Cegonha/Mãe Paulistana will be interviewed; women who had a stillbirth will be interviewed at home 2 months after the fetal death in a sample of 100 cases. Analysis will identify risk factors for still birth, investigate their interrelationships and estimate the individual contributions to fetal mortality in this setting as well as needs for support for bereaved families; results will be disseminated in the policy and scientific community. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BURALLI, RAFAEL JUNQUEIRA; DA SILVA, ZILDA PEREIRA; ALENCAR, GIZELTON PEREIRA; FIGUEIREDO, GERUSA MARIA; HOSHIDA, MARA SANDRA; LUNA, EXPEDITO J. A.; PASTRO, LUCIANA DUZOLINA MANFRE; DOS SANTOS, OSMARA ALVES; MARQUES, LAYS JANAINA PRAZERES; ZERBINATI, RODRIGO MELIM; et al. Assessing the risks for stillbirth in São Paulo, Brazil: protocol for a multidisciplinary case-control study - FetRisks. BMJ OPEN, v. 14, n. 6, p. 10-pg., 2024-06-01. (20/05458-9, 22/16153-0, 16/07765-0, 22/13271-1)