Modulation of metabolic and inflammatory parameters by the hydroalcoholic extract of Musa cavendishii in high fat diet obesity

• Grant number: 17/12843-3
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2018
• End date: August 31, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Thais Martins de Lima Salgado
• Grantee: Thais Martins de Lima Salgado
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Heraldo Possolo de Souza ; Iracelle Carvalho Abreu

Abstract

Obesity is involved in the development of diseases associated with changes in lipid metabolism such as diabetes, dyslipidemias and cardiovascular diseases. Excess lipids stimulate inflammation, which is responsible for changes in insulin signaling. The search for new sources of treatment for the prevention of hyperglycemia and its complications has been intensifying all over the world, including the isolation of active secondary metabolites present in medicinal plants. These plants represent an important alternative pharmacological source because they present a variety of chemical structures and mechanisms of action with potential to reach several targets in the body, favoring the use of smaller doses and consequently, present less risks of side effects. Studies performed at the Research Laboratory in Pharmacology of Natural Products of the Federal University of Maranhão showed the efficiency of the Musa cavendishii extract (EHB) in preventing the elevation of glycemia and lipids in a model of metabolic syndrome. However, the mechanisms involved have not yet been elucidated. Since the EHB has the potential to act in glycemic and lipid metabolism and due to the lack of knowledge of the cellular and molecular mechanisms for which EHB acts, we propose in this project to investigate the effect of the administration EHB on signaling pathways involved in glycemic and lipid metabolism in relevant tissues (skeletal muscle, liver and adipose tissue) of obese mouse induced by ingestion of a high fat diet. In addition, due to the known inflammatory character of the metabolic syndrome (MS), we will evaluate if the effects of EHB are due to the modulation of inflammatory markers in different tissues. Thus, this project proposes to contribute to the understanding of the effects of the oral formulation with the hydroalcoholic extract of the green bark of Musa cavendishii, proving its anti-diabetogenic and hypolipidemic effects. These data will provide scientific background for further study in humans, and provide alternatives for treatment of the metabolic syndrome with low cost and easy acquisition. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARROSO, WERMERSON ASSUNCAO; ABREU, IRACELLE CARVALHO; RIBEIRO, LARISSA SOUSA; DA ROCHA, CLAUDIA QUINTINO; DE SOUZA, HERALDO POSSOLO; DE LIMA, THAIS MARTINS. Chemical composition and cytotoxic screening of Musa cavendish green peels extract: Antiproliferative activity by activation of different cellular death types. TOXICOLOGY IN VITRO, v. 59, p. 179-186, SEP 2019. (17/12843-3)

BARROSO, WERMERSON ASSUNCAO; SERRA, MARIANA BARRETO; ABREU, IRACELLE CARVALHO; BARBEIRO, HERMES VIEIRA; FIAMONCINI, JARLEI; RINALDI DE ALVARENGA, JOSE FERNANDO; DE SOUZA, HERALDO POSSOLO; DE LIMA, THAIS MARTINS. anana green peels extract protects against nonalcoholic fatty liver disease in high-fat-fed mice through modulation of lipid metabolism and inflammatio. Phytotherapy Research, v. 36, n. 2, JAN 2022. (17/12843-3, 13/07914-8, 19/11324-8)