Research Grants 17/19834-0 - Implantodontia, Biologia molecular - BV FAPESP
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Impact of PTFE-d barrier intentionally exposed to bucal environment in guided bone regeneration to ridge preservation: Microbiological, radiographic, patient-centered outcomes, molecular patter of bone-related markers and implant stabilization

Abstract

The aim of this clinical-laboratorial, paralel, randomized, prospective and controlled study will be determine the impact of of PTFE-d barrier intentionally exposed to bucal environment in guided bone regeneration to ridge preservation, using microbiological, radiographic, patient-centered outcomes, molecular patter of bone-related markers and implant stabilization. Fourty individuals with tooth extraction indication and subsequent implant placement between upper pre-molars will be recruited. Patients will be randomly allocated in one of this groups, following tooth extraction: 1) ROG: sockets will receive ROG with d-PTFE membranes which will be maintained intentionally exposed to bucal environment and removed after 28 days; and 2) Non-ROG: sockets will not receive additional therapy after extration. After 3 months, all patients will receive dental implants and temporary implant-supported prostheses. Patient-reported outcomes in terms of morbidity, swelling and interference with daily life will be recorded at 3, 7, 14, 28, 35 and 42 days following dental extraction and in terms of esthetic outcomes after prosthesis instalation by using questionaries. Samples of biofilm at surface repair/barrier will be obtained in both groups at 3 and 28 days after extraction (in the moment of barrier removal)to microbiological evaluation using Illumina HiSeq system. Computed tomography obtained imediatlly after extraction and before implant placement will be analised to evaluation of changes on ridge dimensions. After 3 months following extration, bone tissue biopsies will be harvested from the sites designed to receive dental implants to evaluation of imunoenzimatic pattern (DKK1, OPG, OC, OPN, TNF-±, SOST, RANKL, OSN e TRAP) and gene expression (TGF-², BSP e COL-I) of bone-related markers using Luminex/Magpix and PCR Real-Time, respectivally. Afer imlpant placement, the implant stability quotient (ISQ) will be determined. The results will be compared using ANOVA or Kruskal Wallis, after normality test, with the level of significance set at 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATUMOTO, EDSON KEN; CORREA, MONICA GRAZIELI; COUSO-QUEIRUGA, EMILIO; MONTEIRO, MABELLE FREITAS; GRAHAM, ZACHARY; BRAZ, SILVIA HELENA GARCIA; RIBEIRO, FERNANDA VIEIRA; PIMENTEL, SUZANA PERES; CIRANO, FABIANO RIBEIRO; CASATI, MARCIO ZAFFALON. Influence of partially exposed nonabsorbable membrane for alveolar ridge preservation: A randomized controlled trial. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, v. 25, n. 3, p. 11-pg., . (17/19834-0)