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LONGITUDINAL STUDY OF METABOLIC AND PHYSIOLOGICAL MARKERS IN THE DEVELOPMENT OF OBESITY AND METABOLIC SYNDROME IN RATS FED WITH HYPERLIPIDIC DIETS

Abstract

Obesity is characterized by an increase in adipose tissue and the metabolic stressresulting from this event favors in these tissues local and systemic inflammation. Themain cytokines involved in this process increase the chances of insulin resistance (IR),diabetes mellitus 2 (DM2), arterial hypertension (AH), increased intracranial pressure(ICP), cardiovascular disease (CVD) and Metabolic Syndrome (MS). Among themetabolic complications of obesity, DM2 is characterized by changes in glucosehomeostasis and insulin secretion by pancreas, and it also increases the risk of stroke byincreasing ICP and AH. In this sense, the influence of physical exercise on modulatingmuscle metabolism and the release of inflammatory markers is emphasized. Among thesecreted myokines, irisin, besides exerting beneficial effects on the metabolism ofglucose and lipids, stimulates thermogenesis, lipolysis and transdifferentiation of whiteadipocytes, but nothing is known about its action on ICP and HA. Thus, the objectiveswill be to evaluate and characterize metabolic and pathophysiological markers in thedevelopment of obesity and MS in rats fed a hyperlipid diet, and their interference in theparameters that modify the ICP, HA and irisin. For this, Wistar rats will receive ahyperlipid diet for 24 weeks to induce obesity. Thus, we will determine in this modelthe irisin behavior in the development of obesity and in the interference of the physicalexercise of 8 weeks in addition to its effect on ICP and HA. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES, JOAO MANOEL; GOMES TELES, RAMON HANDERSON; GOMES GATTO, CAMILA DO VALLE; MUNOZ, VITOR ROSETTO; COMINETTI, MARCIA REGINA; GARCIA DE OLIVEIRA DUARTE, ANA CLAUDIA. Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis. CELLS, v. 8, n. 12 DEC 2019. Web of Science Citations: 0.

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