LONGITUDINAL STUDY OF METABOLIC AND PHYSIOLOGICAL MARKERS IN THE DEVELOPMENT OF OBESITY AND METABOLIC SYNDROME IN RATS FED WITH HYPERLIPIDIC DIETS

• Grant number: 17/09602-4
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2018
• End date: May 31, 2020
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Ana Cláudia Garcia de Oliveira Duarte
• Grantee: Ana Cláudia Garcia de Oliveira Duarte
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated researchers: Fernanda de Freitas Anibal ; Sergio Mascarenhas Oliveira

Abstract

Obesity is characterized by an increase in adipose tissue and the metabolic stressresulting from this event favors in these tissues local and systemic inflammation. Themain cytokines involved in this process increase the chances of insulin resistance (IR),diabetes mellitus 2 (DM2), arterial hypertension (AH), increased intracranial pressure(ICP), cardiovascular disease (CVD) and Metabolic Syndrome (MS). Among themetabolic complications of obesity, DM2 is characterized by changes in glucosehomeostasis and insulin secretion by pancreas, and it also increases the risk of stroke byincreasing ICP and AH. In this sense, the influence of physical exercise on modulatingmuscle metabolism and the release of inflammatory markers is emphasized. Among thesecreted myokines, irisin, besides exerting beneficial effects on the metabolism ofglucose and lipids, stimulates thermogenesis, lipolysis and transdifferentiation of whiteadipocytes, but nothing is known about its action on ICP and HA. Thus, the objectiveswill be to evaluate and characterize metabolic and pathophysiological markers in thedevelopment of obesity and MS in rats fed a hyperlipid diet, and their interference in theparameters that modify the ICP, HA and irisin. For this, Wistar rats will receive ahyperlipid diet for 24 weeks to induce obesity. Thus, we will determine in this modelthe irisin behavior in the development of obesity and in the interference of the physicalexercise of 8 weeks in addition to its effect on ICP and HA. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALVES, JOAO MANOEL; GOMES TELES, RAMON HANDERSON; GOMES GATTO, CAMILA DO VALLE; MUNOZ, VITOR ROSETTO; COMINETTI, MARCIA REGINA; GARCIA DE OLIVEIRA DUARTE, ANA CLAUDIA. Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis. CELLS, v. 8, n. 12, DEC 2019. (17/19504-0, 17/09602-4)

FURINO, VANESSA DE OLIVEIRA; ALVES, JOAO MANOEL; MARINE, DIEGO ADORNA; SENE-FIORESE, MARCELA; DOS SANTOS RODRIGUES, CARLA NASCIMENTO; ARRAIS-LIMA, CRISTINA; MATTIELLO, STELA MARCIA; DE CASTRO, CYNTHIA APARECIDA; BORRA, RICARDO CARNEIRO; ROCHA, MARINA CAMPOS; et al. Dietary Intervention, When Not Associated With Exercise, Upregulates Irisin/FNDC5 While Reducing Visceral Adiposity Markers in Obese Rats. FRONTIERS IN PHYSIOLOGY, v. 12, AUG 13 2021. (17/09602-4)

DA COSTA, JEAN LUCAS FERNANDES; FURINO, VANESSA DE OLIVEIRA; DE CASTRO, CYNTHIA APARECIDA; ALVES, JOAO MANOEL; DUARTE, ANA CLAUDIA GARCIA DE OLIVEIRA. Dietary Intervention Associated With Moderate-Intensity Continuous Training Leads to Changes in the Inflammatory Profile in Visceral Adipose Tissue but Not in Skeletal Muscle in Diet-Induced Obese Rats. FRONTIERS IN PHYSIOLOGY, v. 13, p. 10-pg., 2022-03-24. (17/09602-4)