Abstract
The Scientific and Technological Qualification refers to the necessary adaptation to the development of new radiopharmaceuticals, specifically in the phase of scheduling until pilot, within the required quality standards. In addition, one must consider safety issues for manipulation of high radioactive activities, compatible with the scale of industrial production, making it possible to close development cycle for new products, destined to conduct clinical studies in order to demonstrate their efficacy and safety. In addition, this capacitation includes the development of advanced laboratory practices for the chemical and isotopic qualification of radiopharmaceuticals and nanobiomaterials, for health application, via mass spectrometry technique, among others. Radiopharmaceuticals produced at IPEN need assessment by pre-clinical tests for ANVISA approval. This project also aims to carry out research to evaluate the cytotoxic and genotoxic activity of new radiopharmaceutical candidates, as well as to improve radiation detection systems and the processes associated with radiotherapy, nuclear medicine and radio diagnosis, using high performance computing. Considering the qualification in R&D Infrastructure, the project aims to create a nucleus of imaging studies in molecules, cells, tissues and nanoparticles associated to biological processes at IPEN, unprecedented in the country, by SNOM and micro-FTIR, for innovative use in medicine. The proposed techniques will allow mapping of ultrastructural and cellular changes before and after a given treatment, by either laser, nanoparticules, brachytherapy, or radiopharmaceutical. On another front of R&D, the objective is to demonstrate the feasibility of the acceleration of charged particles (electrons/protons/hadrons) in compact systems with lower cost, compared to conventional technologies of acceleration, aiming to proton therapy for nuclear medicine. Closing the virtuous cycle of Innovation and Entrepreneurship, the project aims to improve the management of knowledge and intellectual property generated at IPEN and its interface with the productive sector, in specific actions. (AU)
Scientific publications
(10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORREA, BRUNO S.;
COSTA, MESSIAS S.;
CABRERA-PASCA, GABRIEL A.;
SENA, CLEIDILANE;
PINTO, RAFAEL H.;
SILVA, ANA PAULA S.;
CARVALHO JUNIOR, RAUL N.;
ISHIDA, LINA;
RAMON, JONATHAN G. A.;
FREITAS, RAFAEL S.;
SAIKI, MITIKO;
MATOS, IZABELA T.;
CORREA, EDUARDO L.;
CARBONARI, ARTUR W.
High-saturation magnetization in small nanoparticles of Fe3O4 coated with natural oils.
JOURNAL OF NANOPARTICLE RESEARCH,
v. 22,
n. 3
MAR 6 2020.
Web of Science Citations: 0.
CAMPOS, ALEX C.;
PAES, SUANE C.;
CORREA, BRUNO S.;
CABRERA-PASCA, GABRIEL A.;
COSTA, MESSIAS S.;
COSTA, CLEIDILANE S.;
OTUBO, LARISSA;
CARBONARI, A. W.
Growth of Long ZnO Nanowires with High Density on the ZnO Surface for Gas Sensors.
ACS APPLIED NANO MATERIALS,
v. 3,
n. 1,
p. 175-185,
JAN 2020.
Web of Science Citations: 0.
BOSCH-SANTOS, B.;
NASCIMENTO, N. M.;
SAIKI, M.;
CORREA, E. L.;
SALES, T. S. N.;
PEREIRA, L. F. D.;
CABRERA-PASCA, G. A.;
SAXENA, R. N.;
SCHELL, J.;
CARBONARI, A. W.
Magnetic field at Ce impurities in La sites of La0.5Ba0.5MnO3 double perovskites.
AIP ADVANCES,
v. 9,
n. 3
MAR 2019.
Web of Science Citations: 0.