Guided versus conventional implant surgery: Clinical, radiographic, microbiological, immuno-enzimatic and patient-centered analysis

• Grant number: 18/05376-2
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2018
• End date: January 31, 2021
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Márcio Zaffalon Casati
• Grantee: Márcio Zaffalon Casati
• Host Institution: Vice-Reitoria de Pesquisa e Pós-Graduação. Universidade Paulista (UNIP). São Paulo , SP, Brazil
• Associated researchers: Fabiano Ribeiro Cirano ; Fernanda Vieira Ribeiro ; Mônica Grazieli Corrêa ; Suzana Peres Pimentel

Abstract

The aim of the present clinical, randomized, controlled, double-blind, split-mouth clinical trial is to compare implants installed with flapless guided surgery and conventional surgery, through tomographic, radiographic, immune-inflammatory, microbiological and patient-centered evaluations. For this, 30 total edentulous patients will be selected and maxilar contraletaral quadrants will be randomly assigned to receive: Guided surgery (CG): flapless computer-guided surgery; Conventional surgery (CC): flap surgery with radiographic planning. Patient morbidity experience at intratherapy and during the first postoperative week will be evaluated. Tomography scans will be performed at baseline and 10 days after the surgery to measurement of angular and linear deviations between the implants installed and the computer-planned position. Radiographic evaluations will be performed trough standardized periapical radiography at baseline (day of implant insertion), 3 and 6 months after implant placement for the measurement of peri-implant bone loss. At the time of surgery, the occurrence of complications will be recorded. Peri-implant fluid will be collected at 7, 14, 30 and 90 days after implant insertion for the evaluation of vascular / osteoblast / clastogenesis markers using Luminex / MAGpix assay. Subgingival biofilm will be collected at the same periods for the detection and quantification of periodontal pathogens A. actinomycetencomitans, P. gingivalis, and T. forsythia with real-time PCR technique. After all evaluations, data will be tested for normality (Kolmogorov-Smirnov test) and the statistical methods will be indicated. A significance level of 5% will be adopted for all analysis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NOMIYAMA, LUCAS MASSARU; MATUMOTO, EDSON KEN; CORREA, MONICA GRAZIELI; CIRANO, FABIANO RIBEIRO; RIBEIRO, FERNANDA VIEIRA; PIMENTEL, SUZANA PERES; CASATI, MARCIO ZAFFALON. Comparison between flapless-guided and conventional surgery for implant placement: a 12-month randomized clinical trial. CLINICAL ORAL INVESTIGATIONS, v. N/A, p. 15-pg., 2022-11-19. (18/05376-2)