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Involvement of thyroid hormones on the proliferation, differentiation, and depletion of germ cells by high temperature


Chronic exposures to thermal stress are able to affect the proliferation, differentiation and survival of germ cells. The complete depletion of these cells can result in fully sterile animals. At the genetic level, high temperatures can cause mutations and also induce epigenetic changes in the DNA, with the capacity to be transmitted to next generations, with implications on the survival and the capacity of fish to cope in environments more susceptible to climate changes, especially global warming. This study aims to clarify the regulatory mechanisms (genetic, molecular, and endocrine) involved in the maintenance and differentiation of germ cells in animals exposed to prolonged thermal stress using rainbow trout (Oncorhynchus mykiss) and medaka (Oryzias latipes) as experimental models. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HATTORI, R. S.; CASTANEDA-CORTES, D. C.; ARIAS PADILLA, L. F.; STROBL-MAZZULLA, P. H.; FERNANDINO, J. I. Activation of stress response axis as a key process in environment-induced sex plasticity in fish. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 77, n. 21 MAY 2020. Web of Science Citations: 0.

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