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Involvement of thyroid hormones on the proliferation, differentiation, and depletion of germ cells by high temperature

Grant number: 18/20200-8
Support type:Research Grants - Visiting Researcher Grant - International
Duration: March 11, 2019 - March 17, 2019
Field of knowledge:Agronomical Sciences - Fishery Resources and Fishery Engineering - Aquaculture
Principal Investigator:Ricardo Shohei Hattori
Grantee:Ricardo Shohei Hattori
Visiting researcher: Juan Ignacio Fernandino
Visiting researcher institution: Universidad Nacional de San Martín (UNSAM), Argentina
Home Institution: Departamento de Descentralização do Desenvolvimento (APTA Regional). Secretaria de Agricultura e Abastecimento (São Paulo - Estado). Campinas , SP, Brazil
Associated research grant:13/17612-9 - Genetic characterization, sex control, and germ cell transplantation in salmonids stocks from Estação Experimental de Salmonicultura de Campos do Jordão, AP.JP


Chronic exposures to thermal stress are able to affect the proliferation, differentiation and survival of germ cells. The complete depletion of these cells can result in fully sterile animals. At the genetic level, high temperatures can cause mutations and also induce epigenetic changes in the DNA, with the capacity to be transmitted to next generations, with implications on the survival and the capacity of fish to cope in environments more susceptible to climate changes, especially global warming. This study aims to clarify the regulatory mechanisms (genetic, molecular, and endocrine) involved in the maintenance and differentiation of germ cells in animals exposed to prolonged thermal stress using rainbow trout (Oncorhynchus mykiss) and medaka (Oryzias latipes) as experimental models. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HATTORI, R. S.; CASTANEDA-CORTES, D. C.; ARIAS PADILLA, L. F.; STROBL-MAZZULLA, P. H.; FERNANDINO, J. I. Activation of stress response axis as a key process in environment-induced sex plasticity in fish. CELLULAR AND MOLECULAR LIFE SCIENCES, v. 77, n. 21 MAY 2020. Web of Science Citations: 0.

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