Impact of inspiratory muscle training and aging on metabolic maping and autonomic modulation at rest and on cardiovascular, respiratory and metabolic responses to exercise in healthy men

• Grant number: 16/22215-7
• Support Opportunities: Research Projects - Thematic Grants
• Duration: October 01, 2018 - September 30, 2024
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Aparecida Maria Catai
• Grantee: Aparecida Maria Catai
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Pesquisadores principais: Antonio Gilberto Ferreira ; Regina Vincenzi Oliveira
• Associated researchers: Alberto Porta ; Heloisa Sobreiro Selistre de Araújo ; Renato Lajarim Carneiro ; Tiago Venancio
• Associated scholarship(s): 22/04099-0 - Technical support to the Cardiovascular Physiotherapy Laboratory, BP.TT; 22/02209-3 - Influence of physical exercise and aging on predictors of aerobic fitness and physical health in apparently healthy men, BP.IC; 21/03432-5 - Analysis of inspiratory muscle oxygenation responses to performing the maximal inspiratory pressure maneuver in patients with chronic obstructive pulmonary disease, BP.IC; + associated scholarships 21/02159-3 - Correlation between aerobic fitness and different intensities of activities of daily living by wearable technologies, BP.IC; 20/15769-1 - Technical support to the cardiovascular physiotherapy laboratory in the performance of functional tests in healthy men - part II, BP.TT; 20/13939-7 - Metabolomic analysis by Nuclear Magnetic Resonance (NMR) and mass spectrometry (LC-MS) of blood samples from individuals submitted to cardiorespiratory rehabilitation., BP.PD; 20/01364-0 - Wearables to investigate the relationship between physical activity level, sedentary behavior and aerobic fitness, BP.IC; 19/15040-4 - Omic-based strategies for the investigation of biomarkers for early diagnosis of patients with progressive biliary diseases, BP.DR; 19/19474-9 - Technical support to cardiovascular physiotherapy laboratory in functional testing in healthy men - part III, BP.TT; 19/19615-1 - Technical support to the laboratory of cardiovascular physiotherapy in the execution of functional tests in healthy men - part I, BP.TT; 18/22818-9 - Continuous cardiovascular health evaluation by wearables, BP.DR; 19/10749-5 - Machine learning algorithms for the evaluation of the effect of inspiratory muscle training on the aerobic response in recreational cyclists., BP.PD; 19/10756-1 - Metabolomic analysis by Nuclear Magnetic Resonance of blood samples from individuals submitted to cardiorespiratory rehabilitation., BP.PD; 19/07364-4 - Technical support to the laboratory of cardiovascular physiotherapy in the performance of functional tests in healthy men - part III, BP.TT; 19/03669-5 - Technical support to the laboratory of cardiovascular physiotherapy in the execution of functional tests in healthy men - part III, BP.TT; 19/03672-6 - Technical support to the laboratory of cardiovascular physiotherapy in the execution of functional tests in healthy men - part I, BP.TT; 18/25082-3 - Study of the metabolic profile in active and sedentary aging: metabolomic approach, BP.DD; 18/25519-2 - Analysis of inspiratory muscle oxygenation responses at maximal inspiratory pressure maneuver in healthy men, BP.IC - associated scholarships

Abstract

Background: The inspiratory muscle training (IMT) has brought benefits to many systems, in particular to physical performance improvement. However, there are no consensus regarding the intensities applied as well as on the metabolic pathways involved in the IMT, since these pathways undergo the action of the aging and could be attenuated by physical exercise practice (healthy aging). The present research project consists of two studies. AIMS: Study 1 aims to evaluate the effect of IMT using the respiratory critical pressure (PThCG) compared to the group 60% of MIP (60G) and Sham (SG), on the improvement of physical performance evaluated during the cardiopulmonary exercise testing (CPET), as well as the cardiorespiratory and metabolic responses (muscle oxygenation) during CPET and inspiratory muscle endurance tests in recreational cyclists. Additionally, identify the metabolic pathways activated, metabolomic approach (fingerprint), and the cardiovascular autonomic modulation at rest, after 11 weeks of IMT. Study 2 aims to characterize the metabolic changes (metabolomic approach) of active and non-active aging in men with age between 20-70 years. Methods: In Study 1 thirty men, recreational cyclists (20-40 years), will be evaluated and will perform the following experimental protocol: blood collection, CPET, PThC determination protocol, cardiovascular autonomic assessment at rest; beyond 11 weeks of IMT. In Study 2 one hundred and ten apparently men (55 physical active men), allocated according to decade, will perform the same evaluations of the Study 1, except the IMT and PThC determination protocol. Expected Results: It is expected that after IMT, the PThCG shows higher cardiovascular, respiratory and metabolic demands than the 60G and SG, showing in improvement of physical performance. Moreover, the results from metabolome sheds light on the metabolic pathway activated after IMT in recreational cyclists, as well as the differences between the active and non-active aging. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAIRO, BEATRICE; DE ABREU, RAPHAEL MARTINS; BARI, VLASTA; GELPI, FRANCESCA; DE MARIA, BEATRICE; REHDER-SANTOS, PATRICIA; SAKAGUCHI, CAMILA AKEMI; DA SILVA, CLAUDIO DONISETE; SIGNINI, ETORE DE FAVARI; CATAI, APARECIDA MARIA; et al. Optimizing phase variability threshold for automated synchrogram analysis of cardiorespiratory interactions in amateur cyclists. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND, v. 379, n. 2212, DEC 13 2021. (16/22215-7, 17/13402-0, 18/11123-0)

REHDER-SANTOS, PATRICIA; ABREU, RAPHAEL M.; SIGNINI, ETORE DE F.; DA SILVA, CLAUDIO D.; SAKAGUCHI, CAMILA A.; DATO, CARLA C.; CATAI, APARECIDA M.. Moderate- and High-Intensity Inspiratory Muscle Training Equally Improves Inspiratory Muscle Strength and Endurance-A Double-Blind Randomized Controlled Trial. INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE, v. 16, n. 8, p. 1111-1119, AUG 2021. (19/10749-5, 16/22215-7, 19/03669-5)

DE ABREU, RAPHAEL MARTINS; CATAI, APARECIDA MARIA; CAIRO, BEATRICE; REHDER-SANTOS, PATRICIA; DA SILVA, CLAUDIO DONISETE; SIGNINI, ETORE DE FAVARI; SAKAGUCHI, CAMILA AKEMI; PORTA, ALBERTO. A Transfer Entropy Approach for the Assessment of the Impact of Inspiratory Muscle Training on the Cardiorespiratory Coupling of Amateur Cyclists. FRONTIERS IN PHYSIOLOGY, v. 11, FEB 25 2020. (17/13402-0, 18/11123-0, 16/22215-7)

BELTRAME, THOMAS; GOIS, MARIANA OLIVEIRA; HOFFMANN, UWE; KOSCHATE, JESSICA; HUGHSON, RICHARD LEE; MORAES FRADE, MARIA CECILIA; LINARES, STEPHANIE NOGUEIRA; TORRES, RICARDO DA SILVA; CATAI, APARECIDA MARIA. Relationship between maximal aerobic power with aerobic fitness as a function of signal-to-noise ratio. Journal of Applied Physiology, v. 129, n. 3, p. 522-532, SEP 2020. (18/19016-8, 16/22215-7, 17/09639-5)

DA SILVA, CLAUDIO D.; DE ABREU, RAPHAEL M.; REHDER-SANTOS, PATRICIA; DE NORONHA, MARCOS; CATAI, APARECIDA M.. Can respiratory muscle training change the blood pressure levels in hypertension? A systematic review with meta-analysis. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 31, n. 7, MAR 2021. (16/22215-7)

REHDER-SANTOS, PATRICIA; MINATEL, VINICIUS; MILAN-MATZOS, JULIANA CRISTINA; SIGNINI, ETORE DE FAVARI; DE ABREU, RAPHAEL MARTINS; DATO, CARLA CRISTINA; CATAI, APARECIDA MARIA. Critical inspiratory pressure - a new methodology for evaluating and training the inspiratory musculature for recreational cyclists: study protocol for a randomized controlled trial. Trials, v. 20, MAY 7 2019. (16/22215-7)

DE ABREU, RAPHAEL MARTINS; PORTA, ALBERTO; REHDER-SANTOS, PATRICIA; CAIRO, BEATRICE; DA SILVA, CLAUDIO DONISETE; SIGNINI, ETORE DE FAVARI; SAKAGUCHI, CAMILA AKEMI; CATAI, APARECIDA MARIA. Effects of inspiratory muscle-training intensity on cardiovascular control in amateur cyclists. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 317, n. 6, p. R891-R902, DEC 2019. (17/13402-0, 18/11123-0, 16/22215-7)