Evaluation of Cardiovascular Risk Markers After Moderate Consumption of Different Alcoholic Beverages

• Grant number: 18/09675-4
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2018
• End date: November 30, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eduardo Gomes Lima
• Grantee: Eduardo Gomes Lima
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Carlos Vicente Serrano Junior ; Pedro Henrique de Moraes Cellia

Abstract

Cardiovascular disease remains the first cause of death worldwide and coronary atherosclerosis is the most important etiology of them. In a pathophysiological view alcoholic beverages in moderate doses can act in aterosclerosis plates reducing inflammation, platelets aggregability and improving lipid profile. In this context is well established the concept of a french paradox, which indicates that a regular moderate wine consumption might reduce cardiovascular deaths and improve survival spectice. Many studies have shown that this same benefit could be increased with others alcohol beverages different from wine, even beer and spirits. However the correlation between the brazilian spirit (cachaça) and cardiovascular benefit has not been demonstrated in human trials. This study will analyze the variations of many molecular markers well established as atherosclerosis / cardiovascular risk factors after a period of moderate consume of cachaça and wine, separately.In this period health individuals will be separated in two differents groups: daily moderate consume of cachaça and daily moderate consume of red wine, the equivalent of 30g of alcohol for men and 15g for women. Then, after a abstinence period, both group will change of intervention, in a crossover model. Analysis of cardiovascular markers will be made before and after each intervention in order to compare of the variability.The statistical analysis of the variation of these markers will provide information on the antiatherosclerotic effect of wine and cachaça in humans. (AU)