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Effects of aerobic training on a lipid composition and metabolism and inflamatory response in women under hormonal treatment for breast cancer

Grant number: 18/08032-2
Support type:Regular Research Grants
Duration: March 01, 2019 - February 28, 2021
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Ismael Forte Freitas Júnior
Grantee:Ismael Forte Freitas Júnior
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
Assoc. researchers:Fábio Santos de Lira ; Raul Cavalcante Maranhao ; Rômulo Araújo Fernandes

Abstract

Introduction: Breast cancer is one of the leading causes of morbidity and mortality in the world. Treatment with hormone therapy is usually used after the completion of chemo and / or radiotherapy sessions and decreased the chance of tumor recurrence and metastasis in the patient. However, it has adverse effects such as: loss of bone mineral density, increase in body weight, metabolic changes (lipid and low-grade systemic inflammation), decreased functional capacity and, consequently, lower quality of life. Physical training has been used as a means of reducing these adverse effects, but there is no defined protocol on which training model is effective for patients in this phase of treatment, which is usually done with two categories of medication: Tamoxifen and Inhibitor of Aromatase. Objective: To compare the effect of aerobic training on body composition, metabolic and inflammatory variables, physical activity level and quality of life of women undergoing breast cancer treatment using Tamoxifen and Aromatase Inhibitor. Method: The sample of this randomized clinical trial will consist of 45 women, 15 women without cancer and 30 women under treatment with hormone therapy who are being accompanied by the public service for treatment of breast cancer of the city of Presidente Prudente-SP. Breast cancer survivors will be distributed in two groups in a random way: Tamoxifen Aerobic Training Group (GTT); Aerobic Aromatase Inhibitor Training Group (GTIA), there will also be the Aerobic Training Group without Cancer (GTC) that will not be randomized. The intervention will last 24 weeks, in which the TWG, GTIA and GTC will perform the exercises three times a week on interspersed days and the GTC will be composed of women without cancer who will perform physical training. Evaluations of the variables of interest will be performed at the baseline of the intervention and after 24 weeks of intervention. The following variables will be analyzed: biomarkers (Tumor Necrosis Factor-Alpha (TNF±), interleukin -IL-6 and 10 and adiponectin), body composition variables, lipid profile (triglycerides, total cholesterol and fractions- Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and Very Low Density Lipoprotein (VLDL)), non-HDL cholesterol, glycemia, insulin, free fatty acids, APOA1, APOB, APOB48, oxidized LDL, lipid transfer, HDL and antioxidation, HDL size, subfixation of LDL and HDL, cholesterol and platelets, free cholesterol, level of physical activity, pain and quality of life. Trainings will be performed within the target zone of maximum heart rate. The comparisons between groups at each moment will be performed through the ANOVA one way test for independent samples. The comparisons of the variables of interest at the initial moment and after 24 weeks will be made through the multivariate analysis, where the group effects, time and interaction of both will be compared. In addition to these analyzes, the effect size effect size analysis will also be performed. All analyzes will be performed in SPSS software version 24.0 and significance of 5%. (AU)