Work-related allergic sensitization and asthma: longitudinal studies for characterization and prevention

• Grant number: 17/21035-8
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2019
• End date: March 31, 2026
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Elcio dos Santos Oliveira Vianna
• Grantee: Elcio dos Santos Oliveira Vianna
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Daniela Carlos Sartori ; Edson Zangiacomi Martinez ; Iolanda de Fátima Lopes Calvo Tibério ; Marcelo Bezerra de Menezes ; Marcos de Carvalho Borges ; Michel Reis Messora ; Pedro Henrique Felix Silva ; Rosângela Villela Garcia ; Sergio Luiz de Souza Salvador ; Vivian Marques Miguel Suen
• Associated scholarship(s): 24/18827-3 - Prophylaxis of occupational allergic sensitization in individuals exposed to laboratory animals, BP.PD; 23/08794-8 - Use of Individual and Collective Protection Equipment by Individuals Exposed to Laboratory Animals: Longitudinal Adherence Study., BP.TT; 22/12263-5 - EFFECT OF PROBIOTICS ON INTESTINAL MICROBIOTA: A RANDOMIZED, CONTROLLED STUDY., BP.TT; + associated scholarships 22/06720-4 - EFFECT OF PROBIOTICS ON INTESTINAL MICROBIOTA: A RANDOMIZED, CONTROLLED STUDY., BP.TT; 19/15078-1 - Probiotic microbiological quality: evaluation of time viability and quality of commercial products, BP.IC; 19/13423-3 - Prevention of occupational rhinitis and asthma in sensitized workers exposed to laboratory animals, BP.PD - associated scholarships

Abstract

A multicenter clinical trial performed by our team showed increased prevalence of allergic sensitization among university students and workers dealing with laboratory animals. This occupational sensitization was associated with higher prevalence of asthma, rhinitis and skin symptoms. In the last decades, there have been many reports of increasing prevalence of allergic diseases in childhood and in the general population across the world. Theories and studies have attributed this phenomenon to the reduced contact with microorganisms - hygiene hypothesis. Probiotics are defined as ''live microorganisms which, when administered in adequate amounts, confer a health benefit on the host". They can act as immunomodulatory agents. A guideline panel suggests using probiotics in pregnancy, during breastfeeding and for infants at high risk of developing allergy. We propose a set of national, multicenter, multidisciplinary studies to test the hypothesis of beneficial effects of probiotics on the prevention of allergy, asthma, periodontitis, nutritional abnormalities and constipation symptoms. Our sample will include university students and workers at high risk of work-related allergic diseases. Parallel studies aim to evaluate probiotic effect on potentially responsive clinical conditions; aim to describe mechanisms in clinical and experimental studies; and, aim to control quality of our major studies on allergy prevention. This proposal is innovative, planned according to clinical research difficulties and aimed at optimal yield of human and monetary resources. Expected results include a low cost approach for prophylaxis of diseases that are prevalent, chronic, incurable and related to relevant morbidity and mortality. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MENEGHINI, A. C.; KOENIGKAM-SANTOS, M.; PEREIRA, M. C.; TONIDANDEL, P. R.; TERRA-FILHO, J.; CUNHA, F. Q.; DE MENEZES, M. B.; VIANNA, E. O.. Biomass smoke COPD has less tomographic abnormalities but worse hypoxemia compared with tobacco COPD. Brazilian Journal of Medical and Biological Research, v. 52, n. 5, 2019. (17/21035-8)

COELHO, LIRIS MARINI DIAS; DA FONSECA, VANESSA MACIEL BRAULIO; LABADESSA, IVANA GOLCALVES; SALVADOR, SERGIO LUIZ; MASTRANGE, MARINA DEL ARCO; GEMBRE, ANA FLAVIA; MARTINS, NUBIA SABRINA; BONATO, VANIA LUIZA DEPERON; VIANNA, ELCIO OLIVEIRA; BORGES, MARCOS CARVALHO. The Effect of Lacticaseibacillus rhamnosus, Lacticaseibacillus paracasei, and Bifidobacterium animalis ssp. lactis on the Prevention of Asthma in an Animal Model. PROBIOTICS AND ANTIMICROBIAL PROTEINS, v. N/A, p. 11-pg., 2024-10-09. (17/21035-8)