Fungal receptor-mediated glucose sensing regulates light-dependent development and toxin production

• Grant number: 18/22040-8
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2019
• End date: February 28, 2022
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Agreement: University of Bath
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Gustavo Henrique Goldman
• Grantee: Gustavo Henrique Goldman
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 16/07870-9 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence, AP.TEM

Abstract

A previous A. nidulans genome-wide transcriptomic study showed that three fungal GPCRs, namely gprH, gprI and gprM, were induced during carbon starvation. Consequently, we hypothesize that these three receptors represent a nutrient sensing mechanism that is activated during carbon starvation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOS REIS, THAILA FERNANDA; MELLADO, LAURA; LOHMAR, JESSICA M.; SILVA, LILIAN PEREIRA; ZHOU, JING-JIANG; CALVO, ANA M.; GOLDMAN, GUSTAVO H.; BROWN, NEIL A.. GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production. PLOS GENETICS, v. 15, n. 10, OCT 2019. (17/02464-5, 18/22040-8, 15/12415-6)

JOHNS, LOUISE E.; GOLDMAN, GUSTAVO H.; RIES, LAURE N. A.; BROWN, NEIL A.. Nutrient sensing and acquisition in fungi: mechanisms promoting pathogenesis in plant and human hosts. FUNGAL BIOLOGY REVIEWS, v. 36, p. 1-14, JUN 2021. (17/14159-2, 16/07870-9, 18/22040-8)