A new synergetic path for gas-diffusion microextraction (GDME) making use of molecular imprinted polymers (MIPs)

• Grant number: 18/14425-7
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: May 01, 2019
• End date: April 30, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Luís Francisco Moreira Gonçalves
• Grantee: Luís Francisco Moreira Gonçalves
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Ataualpa Albert Carmo Braga ; Heitor Gabriel Martins Sposito ; Karen Cristina Almeida Francisco
• Associated scholarship(s): 20/04268-1 - Electroanalytical determination of calcium channel blockers making use of molecularly imprinted polymers, BP.IC; 19/24841-0 - Electrochemical determination of metals using paper electrodes, BP.IC; 19/25005-1 - Development of molecular printing polymers (MIPs) by electropolymerization, BP.IC; 19/11214-8 - Application of capillary electrophoresis for the determination of aldehydes after extraction by GDME-MIPs, BP.MS

Abstract

This project aims to demonstrate the potential of the combination of molecularly imprinted polymers (MIPs) with innovative microextraction techniques for sample preparation, namely gas-diffusion microextraction (GDME). Both techniques are relevant in analytical chemistry due to their selectivity, simplicity and ability to obtain enrichment factors. Their combination may have synergistic results; the prior separation made possible by the GDME can increase the efficiency of the MIPs, thus being able to develop more sensitive analytical methodologies. After the GDME-MIP sample preparation step, the methodology may be completed by a detector coupled to a chromatographic column (e.g. HPLC-UV), an electroanalytical detector or even capillary electrophoresis (CE). All these experimental branches are expected to be developed. (AU)

Scientific publications

(24)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PUPIN, RAFAEL ROVATTI; FOGUEL, MARCOS VINICIUS; GONCALVES, LUIS MOREIRA; SOTOMAYOR, MARIA DEL PILAR T.. Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G. Journal of Applied Polymer Science, v. 137, n. 13, APR 5 2020. (18/14425-7, 16/06926-0, 12/14181-4)

MARTINS, ALISSON BEZERRA; LOBATO, ALNILAN; TASIC, NIKOLA; PEREZ-SANZ, FERNANDO J.; VIDINHA, PEDRO; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Laser-pyrolyzed electrochemical paper-based analytical sensor for sulphite analysis. Electrochemistry Communications, v. 107, OCT 2019. (14/50279-4, 18/20745-4, 19/11214-8, 18/13922-7, 17/10522-5, 18/14425-7)

DONEGATTII, TIAGO AUGUSTO; LOBATO, ALNILAN; GONCALVES, LUIS MOREIRA; PEREIRA, ELISABETE ALVES. Cyclohexane-1,3-dione as a derivatizing agent for the analysis of aldehydes by micelar electrokinetic chromatography with diode array detection. ELECTROPHORESIS, v. 40, n. 22, p. 2929-2935, NOV 2019. (11/23286-1, 19/11214-8, 18/14425-7)

GONCALVES, LUIS MOREIRA. HO- and, OH-, Reason and Tradition. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 8, n. 33, p. 3-pg., 2021-10-01. (18/14425-7)

TASIC, NIKOLA; CAVALCANTE, LETICIA; DEFFUNE, ELENICE; GOES, MARCIO SOUSA; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Probeless and label-free impedimetric biosensing of D-dimer using gold nanoparticles conjugated with dihexadecylphosphate on screen-printed carbon electrodes. Electrochimica Acta, v. 397, NOV 20 2021. (18/13922-7, 18/08782-1, 17/10522-5, 18/14425-7)

GROTHE, RENATA A.; LOBATO, ALNILAN; MOUNSSEF, BASSIM; TASI, NIKOLA; BRAGA, ATAUALPA A. C.; MALDANER, ADRIANO O.; ALDOUS, LEIGH; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Electroanalytical profiling of cocaine samples by means of an electropolymerized molecularly imprinted polymer using benzocaine as the template molecule. ANALYST, v. 146, n. 5, p. 1747-1759, MAR 7 2021. (19/05569-8, 18/13922-7, 14/25770-6, 15/01491-3, 18/14425-7, 18/08782-1, 19/11214-8)

MARCO A. G. VALENTE JR.; LUÍS M. GONÇALVES; JULIANO PASSARETTI FILHO; ARNALDO A. CARDOSO; JOSÉ A. RODRIGUES; CECILIO S. FUGIVARA; ASSIS V. BENEDETTI. Corrosion Protection of Steel by Volatile Corrosion Inhibitors: Vapor Analysis by Gas-Diffusion Microextraction and Mass Loss and Electrochemical Impedance in NaCl Deliquescence Tests. Journal of the Brazilian Chemical Society, v. 31, n. 10, p. 2038-2048, 2020-10-09. (18/14425-7)

FERNANDES MANTOANELLI, JESSICA OLIVEIRA; GONCALVES, LUIS MOREIRA; PEREIRA, ELISABETE ALVES. Dansyl Chloride as a Derivatizing Agent for the Analysis of Biogenic Amines by CZE-UV. Chromatographia, v. 83, n. 6, APR 2020. (18/14425-7, 19/03582-7)

TASIC, NIKOLA; MARTINS, ALISSON BEZERRA; YIFEI, XUE; GOES, MARCIO SOUSA; MARTIN-YERGA, DANIEL; MAO, LANQUN; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Insights into electrochemical behavior in laser-scribed electrochemical paper-based analytical devices. Electrochemistry Communications, v. 121, DEC 2020. (18/20745-4, 17/10522-5, 18/13922-7, 18/14425-7)

TASIC, NIKOLA; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Biosensing of D-dimer, making the transition from the central hospital laboratory to bedside determination. Talanta, v. 207, JAN 15 2020. (17/10522-5, 18/08782-1, 18/13922-7, 18/14425-7)

MESA, RUDDY L.; VILLA, JAVIER E. L.; KHAN, SABIR; ALVES PEIXOTO, RAFAELLA R.; MORGANO, MARCELO A.; GONCALVES, LUIS MOREIRA; SOTOMAYOR, MARIA D. P. T.; PICASSO, GINO. Rational Design of an Ion-Imprinted Polymer for Aqueous Methylmercury Sorption. NANOMATERIALS, v. 10, n. 12, DEC 2020. (19/00677-7, 14/50945-4, 18/14425-7)

LUÍS MOREIRA GONÇALVES. Só erra quem faz, e quem faz erra! um manifesto pelo cálculo da propagação de incertezas. Química Nova, v. 43, n. 2, p. 249-252, 2020-05-18. (18/14425-7)

COUTO, ROSA A. S.; MOUNSSEF JR, BASSIM; CARVALHO, FELIX; RODRIGUES, CECILIA M. P.; BRAGA, ATAUALPA A. C.; ALDOUS, LEIGH; GONCALVES, LUIS MOREIRA; QUINAZ, M. BEATRIZ. Methylone screening with electropolymerized molecularly imprinted polymer on screen-printed electrodes. SENSORS AND ACTUATORS B-CHEMICAL, v. 316, JUL 15 2020. (15/01491-3, 14/25770-6, 18/14425-7, 19/05569-8)

BOSSARD, BRUNA; GROTHE, RENATA ANTUNES; MARTINS, ALISSON BEZERRA; LOBATO, ALNILAN; TASIC, NIKOLA; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Nanographene laser-pyrolyzed paper electrodes for the impedimetric detection of D-glucose via a molecularly imprinted polymer. MONATSHEFTE FUR CHEMIE, v. 153, n. 12, p. 7-pg., 2022-10-14. (18/14425-7, 17/10522-5, 18/13922-7, 18/08782-1, 19/11214-8)

COUTO, ROSA A. S.; COSTA, SEFORA S.; MOUNSSEF JR, BASSIM; PACHECO, JOAO G.; FERNANDES, EDUARDA; CARVALHO, FELIX; RODRIGUES, CECILIA M. P.; DELERUE-MATOS, CRISTINA; BRAGA, ATAUALPA A. C.; GONCALVES, LUIS MOREIRA; et al. Electrochemical sensing of ecstasy with electropolymerized molecularly imprinted poly(o-phenylenediamine) polymer on the surface of disposable screen-printed carbon electrodes. SENSORS AND ACTUATORS B-CHEMICAL, v. 290, p. 378-386, JUL 1 2019. (18/14425-7, 14/25770-6, 15/01491-3)

LOBATO, ALNILAN; PEREIRA, ELISABETE ALVES; GONCALVES, LUIS MOREIRA. Combining capillary electromigration with molecular imprinting techniques towards an optimal separation and determination. Talanta, v. 221, JAN 1 2021. (18/14425-7, 19/11214-8)

COUTO, ROSA A. S.; MOREIRA GONCALVES, LUIS. A medical algorithm for Cotard delusion based on more than 300 literature cases. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, v. 25, n. 3, p. 220-232, SEP 1 2021. (18/14425-7)

BENACHIO, INGRID; LOBATO, ALNILAN; GONCALVES, LUIS MOREIRA. Employing molecularly imprinted polymers in the development of electroanalytical methodologies for antibiotic determination. JOURNAL OF MOLECULAR RECOGNITION, v. 34, n. 3, MAR 2021. (18/14425-7, 19/25005-1, 19/11214-8)

COUTO, ROSA A. S.; COELHO, CONSTANTINO; MOUNSSEF, JR., BASSIM; MORAIS, SARA F. DE A.; LIMA, CAMILA D.; DOS SANTOS, WALLANS T. P.; CARVALHO, FELIX; RODRIGUES, CECILIA M. P.; BRAGA, ATAUALPA A. C.; GONCALVES, LUIS MOREIRA; et al. 3,4-Methylenedioxypyrovalerone (MDPV) Sensing Based on Electropolymerized Molecularly Imprinted Polymers on Silver Nanoparticles and Carboxylated Multi-Walled Carbon Nanotubes. NANOMATERIALS, v. 11, n. 2, FEB 2021. (18/14425-7, 15/01491-3, 14/25770-6)

LOBATO, ALNILAN; FERNANDES, VIRGINIA CRUZ; PACHECO, JOAO G.; DELERUE-MATOS, CRISTINA; GONCALVES, LUIS MOREIRA. Organochlorine pesticide analysis in milk by gas-diffusion microextraction with gas chromatography-electron capture detection and confirmation by mass spectrometry. Journal of Chromatography A, v. 1636, JAN 11 2021. (18/14425-7, 19/11214-8)

GONCALVES, LUIS MOREIRA. Electropolymerized molecularly imprinted polymers: perceptions based on recent literature for soon-to-be world-class scientists. CURRENT OPINION IN ELECTROCHEMISTRY, v. 25, FEB 2021. (18/14425-7)

SPOSITO, HEITOR GABRIEL MARTINS; LOBATO, ALNILAN; TASIC, NIKOLA O.; MALDANER, ADRIANO O.; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Swift electrochemical sensing of diltiazem employing highly-selective molecularly-imprinted 3-amino-4-hydroxybenzoic acid. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 911, p. 7-pg., 2022-03-11. (18/13922-7, 18/14425-7, 19/16491-0, 19/11214-8, 17/10522-5, 18/08782-1, 20/04268-1)

QUINTO, MIGUEL LUNA; KHAN, SABIR; VEGA-CHACON, JAIME; MORTARI, BIANCA; WONG, ADEMAR; SOTOMAYOR, MARIA DEL PILAR TABOADA; PICASSO, GINO. Development and Characterization of a Molecularly Imprinted Polymer for the Selective Removal of Brilliant Green Textile Dye from River and Textile Industry Effluents. POLYMERS, v. 15, n. 18, p. 14-pg., 2023-09-01. (19/00677-7, 14/50945-4, 18/14425-7)

DONEGATTI, TIAGO AUGUSTO; LOBATO, ALNILAN; DUEK, ELIANA A. R.; GONCALVES, LUIS MOREIRA; PEREIRA, ELISABETE ALVES. Derivatization-free determination of aminoglycosides by CZE-UV in pharmaceutical formulations. ELECTROPHORESIS, v. 41, n. 18-19, AUG 2020. (18/14425-7, 19/03582-7, 19/11214-8)

Filed patent(s) as a result of this research project