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Obesity and sarcopenia: influence of inflammation and metabolic parameters

Grant number: 16/21384-0
Support type:Regular Research Grants
Duration: July 01, 2019 - June 30, 2021
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Sarah Monte Alegre
Grantee:Sarah Monte Alegre
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:Allan de Oliveira Santos ; Elinton Adami Chaim

Abstract

Sarcopenia is characterized by progressive loss of muscle mass and strength with age associated. The presence of sarcopenia is associated with functional limitations, co-morbidity and mortality increase. The consequences of sarcopenia in the physical dysfunction may worsen in obese individuals. The sarcopenic obesity refers to the presence of sarcopenia and obesity, and is characterized by a smaller amount of muscle in relation to fat. Loss of muscle quality favors the increase in fat infiltration, increased pro-inflammatory cytokines. Studies indicate that inflammation is the link between obesity and sarcopenia, the possible mechanism of inflammation and sarcopenia is in the catabolic action of pro-inflammatory cytokines on muscle. Obesity parameters such as weight, BMI, waist circumference and fat mass, as well as insulin resistance and pro-inflammatory state are inversely correlated with serum levels of vitamin D. Studies have shown increased risk for sarcopenia in men and women with advanced age who had lower levels of 25 [OH] D Objective: to evaluate the presence of sarcopenia in patients with obesity patients, with age between 18 and 59 years, before and after bariatric surgery. Expected results: The presence of sarcopenia in obesity is related to subclinical inflammation frame, worse metabolic profile and body composition, as well as lower levels of vitamin D. (AU)