InGrowth, biomimetic product developed by platelet bioactivation platform: applications in the veterinary and research and development areas

• Grant number: 17/26317-1
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: July 01, 2019
• End date: June 30, 2021
• Field of knowledge: Biological Sciences - Biology
• Agreement: FINEP - PIPE/PAPPE Grant
• Principal Investigator: Sheila Siqueira Andrade
• Grantee: Sheila Siqueira Andrade
• Company: Plateinnove Biotechnology Pesquisas Ltda
• CNAE: Pesquisa e desenvolvimento experimental em ciências sociais e humanas ; Atividades veterinárias
• City: Piracicaba
• Associated researchers: Manoel João Batista Castello Girão
• Associated research grant: 16/14459-3 - Human platelet lysate: from discard to value products in cell therapy and advanced cell-based medicine, AP.PIPE
• Associated scholarship(s): 19/20596-1 - InGrowth, biomimetic product developed by platelet bioactivation platform: veterinary applications and research and development, BP.TT; 19/17724-8 - InGrowth, biomimetic product developed by platelet bioactivation platform: veterinary applications and research and development, BP.TT; 19/15805-0 - Ingrowth, biomimetic product developed by platelet bioactivation platform: applications in the veterinary and research and developed areas, BP.PIPE

Abstract

Founded in 2017 and located in the city of Piracicaba, São Paulo, PlateInnove Biotechnology is a pioneer startup in Brazil and since its conception has been aimed at "disruption innovation" in the area of growth factors. Through the development of a biotechnology platform, in which platelets (raw material), are selectively bio-modulated with consequent production of a panel of customized growth factors. As the production line is based on PlateInnove Platform, these growth factors will be used in our scientific research for two purposes: 1) InGrowth components, an effective cellular nutrition solution, which guarantees both the proliferation of human cells and the characteristics biological / functional cellular, in the molecular aspect. The perfect supplementation for the humanization of cellular assays, an alternative for researchers who seek translational research and industrial scaling; and b) InGrowth-Pet components, an input used by PlateInnove for the development of veterinary formulations for topical use aimed at treating dermatitis and regenerating the skin of animals. Given this scenario, we anticipate the future of biotechnology to mark the path of PlateInnove Biotech (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FARIA, ALESSANDRA V. S.; YU, BINGTING; MOMMERSTEEG, MICHIEL; DE SOUZA-OLIVEIRA, PATRICIA F.; ANDRADE, SHEILA S.; SPAANDER, MANON C. W.; DE MAAT, MONIEK P. M.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, V, CARMEN; FUHLER, GWENNY M.. Platelet-dependent signaling and Low Molecular Weight Protein Tyrosine Phosphatase expression promote aggressive phenotypic changes in gastrointestinal cancer cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1868, n. 1, JAN 1 2022. (17/26317-1, 18/00736-0, 16/14459-3, 17/08119-8, 15/20412-7)

FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, CARMEN V.; FUHLER, GWENNY M.. Platelets in aging and cancer-"double-edged sword". CANCER AND METASTASIS REVIEWS, v. 39, n. 4, p. 17-pg., 2020-09-01. (16/14459-3, 17/08119-8, 18/00736-0, 17/26317-1, 15/20412-7)

ANDRADE, SHEILA SIQUEIRA; DE SOUSA FARIA, ALESSANDRA VALERIA; GIRAO, MANOEL JOAO BATISTA C.; FUHLER, GWENNY M.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, CARMEN, V. Biotech-Educated Platelets: Beyond Tissue Regeneration 2.0. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 17, p. 14-pg., 2020-09-01. (15/20412-7, 16/14459-3, 17/26317-1)

FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, CARMEN V.; FUHLER, GWENNY M.. Platelets in aging and cancer-{''}double-edged sword{''}. CANCER AND METASTASIS REVIEWS, v. 39, n. 4, SI, SEP 2020. (17/08119-8, 17/26317-1, 16/14459-3, 15/20412-7, 18/00736-0)

ANDRADE, SHEILA SIQUEIRA; DE SOUSA FARIA, ALESSANDRA VALERIA; QUELUZ, DAGMAR DE PAULO; FERREIRA-HALDER, CARMEN VERISSIMA. Platelets as a `natural factory' for growth factor production that sustains normal (and pathological) cell biology. Biological Chemistry, v. 401, n. 4, p. 471-476, APR 2020. (16/14459-3, 17/26317-1)

FARIA, ALESSANDRA V. S.; ANDRADE, SHEILA S.; PEPPELENBOSCH, MAIKEL P.; FERREIRA-HALDER, V, CARMEN; FUHLER, GWENNY M.. The role of phospho-tyrosine signaling in platelet biology and hemostasis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1868, n. 3, MAR 2021. (15/20412-7, 17/26317-1, 17/08119-8, 16/14459-3, 18/00736-0)

ANDRADE, SHEILA SIQUEIRA; DE SOUSA FARIA, ALESSANDRA VALERIA; QUELUZ, DAGMAR DE PAULO; FERREIRA-HALDER, CARMEN VERISSIMA. Platelets as a 'natural factory' for growth factor production that sustains normal (and pathological) cell biology. Biological Chemistry, v. 401, n. 4, p. 6-pg., 2020-04-01. (16/14459-3, 17/26317-1)