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Evaluation of cytokines elaborated for platelet during the development of periodontal repair and disease in rats treated or not with antiplatelets drugs

Grant number: 10/10715-9
Support Opportunities:Regular Research Grants
Duration: January 01, 2011 - December 31, 2012
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Luis Carlos Spolidorio
Grantee:Luis Carlos Spolidorio
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Angiogenesis is a critical process in inflammation, central to the contribution of immune cells to the site of aggression. In the process of tissue repair, angiogenesis is important for the access of nutrients and biological mediators to the affected area. Platelets are a natural reservoir of several biological mediators, including several growth factors with angiogenic action. Aggregation and platelet activation depends on several endogenous factors such as adenosine diphosphate (ADP), thrombin and thromboxane A2 (TXA2) and exogenous stimuli including the innate immune response, such as lipopolysaccharide (LPS). In response to activation, platelets express several chemokines, including CXCL4, RANTES (CCL5), CXCL5, and chemokine receptors, including SDF-1/CXCL12. Thus, besides being involved in the processes of hemostasis and tissue repair, platelets participate in the innate and adaptive immune response. Thus, our hypothesis is that drugs capable of inhibiting platelet activation and aggregation can influence the immune/inflammatory response and modulate both the progression on the repair in periodontal disease by interfering in the production of chemokines and growth factors pro- angiogenic. Aspirin irreversibly inactivates the enzyme activity of cyclooxygenase-1 (COX-1) and hence the synthesis of TXA2, by diffusion through the membrane of platelets, whereas clopidogrel acts by irreversibly inactivating platelet P2Y12 receptor, expressed on the membrane platelet and which has as ligand ADP. The objectives of this study are to evaluate the profile of the inflammatory immune response and induction of angiogenesis and subsequent tissue repair in rats treated with aspirin and clopidogrel. The effects of antiplatelet drugs in cells of the innate and adaptive immune response will be evaluated in vitro. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COIMBRA, LEILA S.; STEFFENS, JOAO PAULO; ROSSA, JR., CARLOS; GRAVES, DANA T.; SPOLIDORIO, LUIS C.. Clopidogrel enhances periodontal repair in rats through decreased inflammation. JOURNAL OF CLINICAL PERIODONTOLOGY, v. 41, n. 3, p. 295-302, . (10/10715-9)
COIMBRA, L. S.; STEFFENS, J. P.; MUSCARA, M. N.; ROSSA, JR., C.; SPOLIDORIO, L. C.. Antiplatelet drugs reduce the immunoinflammatory response in a rat model of periodontal disease. JOURNAL OF PERIODONTAL RESEARCH, v. 49, n. 6, p. 729-735, . (10/10715-9)
SPOLIDORIO, LUIS CARLOS; RAMALHO LUCAS, PABLO DALLARI; STEFFENS, JOAO PAULO; BUENO DA SILVA, HENRIQUE APARECIDO; EUZEBIO ALVES, VANESSA TUBERO; PALOMARI SPOLIDORIO, DENISE M.; HOLZHAUSEN, MARINELLA. Influence of Parstatin on Experimental Periodontal Disease and Repair in Rats. Journal of Periodontology, v. 85, n. 9, p. 1266-1274, . (10/16605-0, 10/10715-9)

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