Mortality due to congenital syphilis in the State of São Paulo

• Grant number: 19/03799-6
• Support Opportunities: Research Grants - Research in Public Policies
• Start date: September 01, 2019
• End date: August 31, 2021
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Agreement: CNPq - PPSUS
• Principal Investigator: Carla Gianna Luppi
• Grantee: Carla Gianna Luppi
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Adriana Sanudo ; Angela Tayra ; Beatriz da Costa Thome ; Carlos Roberto Veiga Kiffer ; Carmen Silvia Bruniera Domingues ; Daniela Testoni Costa Nobre ; Daniela Vinhas Bertolini ; Giselle Garcia Origo ; maria aparecida da silva ; Mariana Cabral Schveitzer ; Mariza Vono Tancredi ; Marli de Fátima Prado ; Rita de Cássia Xavier Balda ; Roberto José Carvalho da Silva ; Valdir Monteiro Pinto
• Associated scholarship(s): 20/11370-7 - Congenital syphilis mortality in the State of São Paulo, BP.TT; 19/27081-7 - Congenital syphilis mortality in the State of São Paulo, BP.TT; 19/26372-8 - Congenital syphilis mortality in the State of São Paulo, BP.TT

Abstract

Congenital syphilis (SC) constitutes an important public health problem due to its magnitude, transcendence and the existence of effective prevention and control measures. Between 2009 and 2016, there was a 4.7-fold increase in the incidence rate of SC (TISC) in the state of São Paulo (ESP), in 2016 3,801 cases of SC were reported, corresponding to a TISC of 6.3 cases per 1,000 live births (NV). This increase in the number of cases was accompanied by an increase in the occurrence of unfavorable outcomes of SC: abortion, stillbirth or death; in 2016 10% of the cases presented this unfavorable evolution. The objective of this study will be to investigate the unfavorable outcomes, death, stillbirth and abortion, by SC occurring in the state of São Paulo, between 2007 and 2018. Methods: the study universe will be the data for all cases reported in the ESP of SC from 2007 to 2018. Secondary data from the Sinan Disease Information System, the Mortality Information System (SIM) and the syphilis vertical transmission investigation protocol will be analyzed. The research will be conducted in three stages: database organization, historical series analysis with aggregated data; and analysis of factors associated with congenital syphilis with individual data. Expected results: The analysis and discussion of these results will allow the development of public policies to reduce the number of unfavorable outcomes related to congenital syphilis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FESTA, LARISSA; PRADO, MARLI DE FATIMA; JESUINO, AMANDA CRISTINA SANTOS; BALDA, RITA DE CASSIA XAVIER; TAYRA, ANGELA; SANUDO, ADRIANA; TANCREDI, MARIZA VONO; DA SILVA, MARIA APARECIDA; PINTO, VALDIR MONTEIRO; COSTA-NOBRE, DANIELA TESTONI; et al. Underreporting of unfavorable outcomes of congenital syphilis on the Notifiable Health Conditions Information System in the state of Sao Paulo, Brazil, 2007-2018. EPIDEMIOLOGIA E SERVICOS DE SAUDE, v. 32, n. 2, p. 11-pg., 2023-01-01. (19/03799-6)