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Epidemiological study of congenital syphilis: the reality of a tertiary teaching hospital

Grant number: 17/00332-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2017
Effective date (End): March 31, 2018
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal researcher:Maria Regina Bentlin
Grantee:Patrícia Akemi Tabuchi
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Syphilis is an important public health problem not only because of the increasing number of cases in the general population but also in pregnant women, since in this situation the infection can be transmitted to the fetus with serious implications. The goal of the Pan American Health Organization and the United Nations Children's Fund was to reduce the incidence of congenital syphilis to below 0.5 per 1,000 live births by 2015. Unfortunately this fact did not happen, instead the rates continued to rise. In Brazil the incidence more than doubled in the last decade reaching more than 4 per 1000 live births. One of the possible causes for this increase may be the late diagnosis of the pregnant woman and her inadequate treatment. Objective: To determine the incidence of congenital syphilis and to propose educational and preventive measures for its reduction; To characterize the profile of newborns with congenital syphilis and their mothers; To determine the main forms of presentation of congenital syphilis; Prepare educational pamphlets on the disease to be distributed in the basic network; To promote discussions about syphilis among health professionals and pregnant women who are prenatal in the basic network Methodology: A retrospective epidemiological study to be carried out at the Maternity Hospital of the Botucatu Medical School - UNESP, already approved by the Institution's Ethics Committee and with FAPESP funding (2016/ 10681-3). All notified cases of mothers with positive VDRL at delivery and their respective newborns between January 2015 to December 2016 will be selected. There will be no exclusion criteria. The sample will be of convenience. Maternal variables (age, prenatal, drug use, serology and treatment for syphilis), neonatal (birth weight, gestational age, clinical and laboratory manifestations of syphilis, blood and CSF serology) will be evaluated. The search for information will be carried out in patient charts. The data will be tabulated in spreadsheets with subsequent descriptive analysis with mean and standard deviation and proportions. Educational pamphlets will be made and distributed in the region's basic networks. Basic health units from 5 strategic cities will receive a visit from the researchers (advisor and student of scientific initiation) to present the results and discuss syphilis and congenital syphilis with health professionals and pregnant women. Expected results: To contribute to the diagnosis of the congenital syphilis situation in a region of São Paulo State and based on the data found, propose strategies for prevention, diagnosis and appropriate treatment of pregnant women in an attempt to reduce the incidence of maternal disease and its complications to the newborn. Promote and facilitate the diffusion of knowledge between university and community, and create a channel of dialogue between them. (AU)

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