Evaluation of photoactivity of porphyrin-conjugated ternary quantum dots

• Grant number: 19/20111-8
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: January 03, 2020
• End date: January 23, 2020
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Dayane Batista Tada
• Grantee: Dayane Batista Tada
• Visiting researcher: Samuel Oluwatobi Oluwafemi
• Visiting researcher institution: University of Johannesburg (UJ), South Africa
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil

Abstract

The conjugation of a photosensitizer (PS) to a nanoparticle (NP) creates the well-known photosensitizing nanoparticles which have been widely explored for application in Photodynamic Therapy (PDT). In comparison with the application of a PS in solution, the use of photosensitizing NPs provides improved tumor targeting and circulation time. Also, photosensitizing NPs can enhance therapeutic efficiency of PS by protecting them from deactivation as well as by avoiding PS aggregation and providing the modulation of PS photoactivity. In addition to these advantages the development of a photosensitizing NP by conjugating the PS to a ternary quantum dot will also enable the application of the NPs as agents for diagnosis by fluorescence. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

HURTADO, CAROLINA RAMOS; HURTADO, GABRIELA RAMOS; DE CENA, GABRIELLE LUPETI; QUEIROZ, RAFAELA CAMPOS; SILVA, ALEXANDRE VIEIRA; DINIZ, MILTON FARIA; DOS SANTOS, VERONICA RIBEIRO; TRAVA-AIROLDI, VLADIMIR; BAPTISTA, MAURICIO DA SILVA; TSOLEKILE, NCEDIWE; et al. Diamond Nanoparticles-Porphyrin mTHPP Conjugate as Photosensitizing Platform: Cytotoxicity and Antibacterial Activity. NANOMATERIALS, v. 11, n. 6, JUN 2021. (19/09737-2, 19/20111-8, 17/01697-6)

TSOLEKILE, NCEDIWE; PARANI, SUNDARARAJAN; DE MACEDO, ERENILDA FERREIRA; LEBEPE, THABANG CALVIN; MALULEKE, RODNEY; NCAPAYI, VUYELWA; MATOETOE, MANGAKA CLARA; SONGCA, SANDILE PHINDA; CONCEICAO, KATIA; TADA, DAYANE BATISTA; et al. Photodynamic Therapy and Antibacterial Activities of a Novel Synthesized Quaternary Zn-Cu-In-S/ZnS QDs- mTHPP Porphyrin Conjugate. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 17, p. 11-pg., 2022-01-01. (19/20111-8)