Plasma pharmacokinetics and tissue biodistribution of lipid-based nanoformulations

• Grant number: 19/17784-0
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2020
• End date: November 30, 2022
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Agreement: CONFAP - National Council of State Research Support Foundations
• Principal Investigator: Eneida de Paula
• Grantee: Eneida de Paula
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Bibiana Verlindo de Araujo

Abstract

Nanostructured lipid carriers (CLN) are suitable for the encapsulation of hydrophobic drugs, offering a series of advantages over other drug-delivery carriers such as: biocompatibility, biodegradability, non-immunogenicity, relative low cost, no requirement of organic solvents and scalability. Aiming to stablish a collaborative research network between the Biomembranes laboratory (Unicamp) and the Pharmacokinetics and PK/PD Modeling Laboratory (UFRGS) in the biotechnological area, this project intends to evaluate the pharmacokinetics, as well as the free drug concentrations of CLN-encapsulated drugs at target tissues using microdialysis. Two types of drug delivery systems will be investigated in animal models of disease: CLN containing either doxorrubicin or a photosensitizer agent for the treatment of breast cancer - using chemo or photodynamic therapy - and CLN uploaded with articaine for the anesthesia of inflamed tissue. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES DA SILVA, GUSTAVO HENRIQUE; DE MOURA, LUDMILLA DAVID; DE CARVALHO, FABIOLA VIEIRA; GERONIMO, GABRIELA; MENDONCA, TALITA CESARIM; DE LIMA, FERNANDO FREITAS; DE PAULA, ENEIDA. Antineoplastics Encapsulated in Nanostructured Lipid Carriers. Molecules, v. 26, n. 22, NOV 2021. (19/17784-0, 21/02617-1, 18/12121-0, 20/01237-8, 17/15174-5)

DE MOURA, LUDMILLA DAVID; RIBEIRO, LIGIA N. M.; DE CARVALHO, FABIOLA V.; RODRIGUES DA SILVA, GUSTAVO H.; LIMA FERNANDES, PRISCILA C.; BRUNETTO, SERGIO Q.; RAMOS, CELSO D.; VELLOSO, LICIO A.; DE ARAUJO, DANIELE R.; DE PAULA, ENEIDA. Docetaxel and Lidocaine Co-Loaded (NLC-in-Hydrogel) Hybrid System Designed for the Treatment of Melanoma. PHARMACEUTICS, v. 13, n. 10, OCT 2021. (19/17784-0)

RODRIGUES DA SILVA, GUSTAVO H.; MENDES, LUIS F.; DE CARVALHO, FABIOLA, V; DE PAULA, ENEIDA; DUARTE, IOLA F.. Comparative Metabolomics Study of the Impact of Articaine and Lidocaine on the Metabolism of SH-SY5Y Neuronal Cells. METABOLITES, v. 12, n. 7, p. 17-pg., 2022-07-01. (14/14457-5, 18/24814-0, 19/17784-0)

RODRIGUES DA SILVA, GUSTAVO HENRIQUE; PAES LEMES, JULIA BORGES; GERONIMO, GABRIELA; DE CARVALHO, FABIOLA VIEIRA; MENDONCA, TALITA CESARIM; MALANGE, KAUE FRANCO; DE LIMA, FERNANDO FREITAS; BREITKREITZ, MARCIA CRISTINA; PARADA, CARLOS AMILCAR; DALLA COSTA, TERESA; et al. Improved Local Anesthesia at Inflamed Tissue Using the Association of Articaine and Copaiba Oil in Avocado Butter Nanostructured Lipid Carriers. PHARMACEUTICALS, v. 16, n. 4, p. 18-pg., 2023-04-01. (19/17784-0, 17/15174-5)