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Design of different fragments of SARS-CoV-2 surface protein spike for the development of fast diagnostic test and vaccine

Abstract

Our research group, in collaboration with researcher Dr. Edison Durigon of ICB USP, is developing a fast diagnostic tests to detect COVID-19. For this, we have already clone and express 4 fragments of the SARS-CoV-2 surface protein spike and have shown to be immonogenic against the serum of a human patient. For the production of the fast diagnostic test, proteins were produced on a large scale to inoculate in three animals (rat, rabbit and goat). We started inoculating three proteins in rats, goats and rabbits. The forecast is that in 21 days we will have enough serum to produce the first rapid tests. Due to the demand and urgency in the production of these fragments of the spike, I am coordinating a task force that also involves Prof. Shaker Chuck Farah to produce the 4 spike fragments in large scale both to continue inoculation in animals and to do other tests. We have also already synthesised new oligo to build 4 more fragments of the virus's spike protein to try to obtain soluble proteins for vaccine development, this part of the project will be done in collaboration with Prof. Durigon and with Profa. Dra. Ana Marcia also from ICB USP. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DANIELLE BASTOS ARAUJO; RAFAEL RAHAL GUARAGNA MACHADO; DEYVID EMANUEL AMGARTEN; FERNANDA DE MELLO MALTA; GABRIEL GUARANY DE ARAUJO; CAIRO OLIVEIRA MONTEIRO; ERIKA DONIZETTI CANDIDO; CAMILA PEREIRA SOARES; FERNANDO GATTI DE MENEZES; ANA CAROLINA CORNACHIONI PIRES; RÚBIA ANITA FERRAZ SANTANA; AMANDA DE OLIVEIRA VIANA; ERICK DORLASS; LUCIANO THOMAZELLI; LUIS CARLOS DE SOUSA FERREIRA; VIVIANE FONGARO BOTOSSO; CRISTIANE RODRIGUES GUZZO CARVALHO; DANIELLE BRUNA LEAL OLIVEIRA; JOÃO RENATO REBELLO PINHO; EDISON LUIZ DURIGON. SARS-CoV-2 isolation from the first reported patients in Brazil and establishment of a coordinated task network. Memórias do Instituto Oswaldo Cruz, v. 115, p. -, 2020.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.