Influence of maternal and paternal intake of hyperlipidic/hyperglycidic diet on the colon-hypothalamus of the offspring in the early adult life

• Grant number: 19/09724-8
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2020
• End date: April 30, 2022
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Luciana Pellegrini Pisani
• Grantee: Luciana Pellegrini Pisani
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Associated researchers: Laís Vales Mennitti ; Lila Missae Oyama

Abstract

Recently, a high-fat diet has been associated with hypothalamic low-grade inflammation, and dysregulation of energy and metabolic control that can lead to the development of obesity. In this process, the connection between gut and brain seems to be involved in the alterations that lead to the development of chronic diseases. Considering the evidence that an inadequate maternal diet, and more recently a paternal diet, can program the offspring to develop chronic diseases into adulthood, it will be assess the effects of maternal and paternal high fat/high sugar on the programming of the hypothalamus and colon from the 90-day old offspring. Therefore, it will assess in the 90-day old offspring from parents who had high fat/high sugar or control diets, the following parameters. Serum fatty acids profile; hypothalamic and colonic relative weight; leptin and insulin content in the hypothalamus; cytokines TNF-±, IL-6, IL10 and LPS content in the hypothalamus and colon; TLR4 content and proteins involved in the TLR4 pathway MYD88, NFkB fosforilado (p50 e p65) content in the hypothalamus and colon; ZO-1 content in the hypothalamus and colon; quantification of Lactobacillus and Bifidobacterium DNA in the stools. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CESAR, HELENA; SERTORIO, MARCELA NASCIMENTO; SANTAMARINA, ALINE; DE SOUZA, ESTHER ALVES; MENNITTI, LAIS VALLES; JAMAR, GIOVANA; JUCA, ANDREA; CASAGRANDE, BRENO PICIN; ESTADELA, DEBORA; PISANI, LUCIANA PELLEGRINI. The influence of parental high-fat high-sugar diet on the gut-brain axis in male offspring. Food Research International, v. 160, p. 11-pg., 2022-07-26. (17/09646-1, 19/09724-8)

SERTORIO, MARCELA NASCIMENTO; ESTADELLA, DEBORA; RIBEIRO, DANIEL ARAKI; PISANI, LUCIANA PELLEGRINI. Could parental high-fat intake program the reproductive health of male offspring? A review. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, AUG 2021. (19/09724-8, 18/17412-3)

SERTORIO, MARCELA NASCIMENTO; CESAR, HELENA; DE SOUZA, ESTHER ALVES; MENNITTI, LAIS VALES; SANTAMARINA, ALINE BOVETO; MESQUITA, LEONARDO MENDES DE SOUZA; JUCA, ANDREA; CASAGRANDE, BRENO PICIN; ESTADELLA, DEBORA; AGUIAR JR, ODAIR; et al. Parental High-Fat High-Sugar Diet Intake Programming Inflammatory and Oxidative Parameters of Reproductive Health in Male Offspring. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 10, p. 13-pg., 2022-06-27. (18/17412-3, 19/09724-8)