Development of multiscale surface treatment for titanium based implants

• Grant number: 19/10484-1
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: August 01, 2020
• End date: December 31, 2022
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Diego Pedreira de Oliveira
• Grantee: Diego Pedreira de Oliveira
• Company: Extremus Smart Surface - Tratamentos de Superfície Ltda
• CNAE: Atividades profissionais, científicas e técnicas não especificadas anteriormente
• Principal investigators: Luis Felipe Sverzut Baroni
• Associated research grant: 16/08359-6 - Multiscale osteoconductive surface coating for titanium based implants, AP.PIPE
• Associated scholarship(s): 21/06067-6 - Biological evaluation, reproducibility, and characterization of modified surfaces of titanium-based implants., BP.TT; 20/09462-0 - Development of multiscale surface treatment for titanium based implants, BP.PIPE

Abstract

Currently biomaterials can present key features that promote specific biological activities at the cellular level optimizing systemic responses that accelerate the recovery process of patients. In the competitive scenario of implants for both medicine and dentistry, the interactions of the surface of the material with the physiological environment are determinant to favor osseointegration of endosseous implants. For this, surfaces are developed with structures from macro, micro, submicro to nano metric levels. Macro scales involve dimensions over 10 micrometers (¼m); between 1 and 10 ¼m; the submicron level comprises dimensions between 1 ¼m and 100 nanometers (nm), while nanometric structures are observed with dimensions below 100 nm [1]. Researchers focus efforts to develop standardized topography features in macro, micro, submicron and nano scales with potential to favor and considerably control mechanical fixation and biological events prior to reconstruction of damaged tissues due to some substitutable trauma, disease or congenital factors by implants. Extremus focuses on the technology developed by Extremus to apply topographic micro and nano technology to the surface of dental implants on an industrial scale with companies / partners / clients. Our proposal aims at staggering the production and quality control of surfaces in dental implants. Relying on the ever more demanding and competitive market that projects from both a cost and performance standpoint, we focus on developing a technically and reliably viable process. (AU)