Non-coding RNAs involved with melanoma genesis and progression
| Grant number: | 19/23480-4 |
| Support type: | Regular Research Grants |
| Duration: | March 01, 2020 - February 28, 2022 |
| Field of knowledge: | Biological Sciences - Biochemistry - Molecular Biology |
| Mobility Program: | SPRINT - Projetos de pesquisa - Mobilidade |
| Principal Investigator: | Miriam Galvonas Jasiulionis |
| Grantee: | Miriam Galvonas Jasiulionis |
| Principal investigator abroad: | Gangning Liang |
| Institution abroad: | University of Southern California (USC), United States |
| Home Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
| Associated research grant: | 18/20775-0 - Non-coding RNAs involved with melanoma genesis and progression, AP.R |
Abstract
This proposal aims to strength our hypothesis that epi-drugs, such as demethylating agents, can be an effective treatment for eliminating residual tumor cells by treating both resistant and/or dormant tumor cells (seed) and the microenvironment (soil). The proposal is based on two immunocompetent models: the cellular model of murine melanoma and the model of microenvironment-dependent tumor growth. These two approaches have a parallel with important aspects in the clinics: the first is related to circulating tumor cells remaining after removing a tumor by surgery (residual tumor cells); alternatively, our model of tumor growth from a very small number of tumor cells induced by the presence of a massive number of apoptotic cells has a parallel with tumor cells remaining after treatments inducing massive apoptosis, such as radio- and chemotherapy, which can favor the growth of remaining viable cells. (AU)