Yellow Fever vaccine efficacy in patients with surgical remove of the thymus after neonatal congenital heart disease repair

• Grant number: 19/25240-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2020
• End date: November 30, 2021
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Paulo Henrique Manso
• Grantee: Paulo Henrique Manso
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Benedito Antônio Lopes da Fonseca ; Luiza Antunes de Castro Jorge ; Vitor Gonçalves Floriano

Abstract

Yellow Fever is an endemical viral borne disease, prevented by vaccination. However, for its efficacy, the patient must be immunocompetent. Patients who were submitted to open heart surgery in the neonatal period usually have the thymus surgically removed. The objective of this project is to evaluate wheter these patients present an adequate response to Yellow Fever virus. (AU)