Stereidogenic controle of intrauterine sexual diferentiation in capyvaras (Hydrochaeris hydrochaeris)

• Grant number: 19/03138-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2020
• End date: April 30, 2023
• Field of knowledge: Biological Sciences - Zoology - Morphology of Recent Groups
• Principal Investigator: Antônio Chaves de Assis Neto
• Grantee: Antônio Chaves de Assis Neto
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Cristiane Schilbach Pizzutto

Abstract

The aim of the present study is to establish the patterns of morphological development, molecular characteristics and possible quantitative variations of 5-alpha-reductase enzymes, cytochrome P450aromatase, cytochrome P450c17, 3²-HSD, 17²-HDS and STAR enzymes throughout the different stages of capybara gestation. For this research will be analyzed 30 concepts in the early, intermediate and final stages of gestation. To date, 10 placentas with embryos/fetuses were collected throughout the different stages of pregnancy (initial, intermediate and final stages of pregnancy). Throughout the research, morphological development patterns of embryos and fetuses will be established through macroscopic dissections, histological and ultrastructural analyzes, molecular evaluations of the gonads, adrenals of male and female embryos/fetuses, and placenta. The expression of the anti-Müllerian hormones and androgen receptors in the ovaries in the different gestational stages will also be evaluated. The study will be able to understand the relationship between gestation and the stereogenic mechanisms of sexual differentiation, the formation of the genital organs of males and females, and the implications in the context of the sexual dimorphism of the species. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDA BATTISTELLA PASSOS-NUNES; FABIANA MORSE GOSSON JORGE; MARIANA PASSOS NUNES; ALEXANDRE ZANETTI NUNES; PEDRO NACIB JORGE-NETO; ANTONIO CHAVES DE ASSIS NETO; MARCELO BAHIA LABRUNA; CRISTIANE SCHILBACH PIZZUTTO. Surgical sterilization of free-ranging capybaras (Hydrochoerus hydrochaeris): “Passos Nunes” uterine horn ligature. Animal Reproduction, v. 19, n. 2, 2022-08-08. (19/03138-0)

JORGE, FABIANA M. G.; DONOSO, FLAVIA MARIA PIA MONTENEGRO; ALCOBACA, MAYLA MAGALHAES DE OLIVEIRA; CRISTOFOLI, MARILU; PASSOS NUNES, FERNANDA B.; PIZZUTTO, CRISTIANE S.; ASSIS NETO, ANTONIO CHAVES DE. Surgical Anatomy for Sterilization Procedures in Female Capybaras. ANIMALS, v. 13, n. 3, p. 14-pg., 2023-02-01. (19/03138-0)

PASSOS-NUNES, FERNANDA BATTISTELLA; GOSSON JORGE, FABIANA MORSE; NUNES, MARIANA PASSOS; NUNES, ALEXANDRE ZANETTI; JORGE-NETO, PEDRO NACIB; DE ASSIS NETO, ANTONIO CHAVES; LABRUNA, MARCELO BAHIA; PIZZUTTO, CRISTIANE SCHILBACH. Surgical sterilization of free-ranging capybaras (Hydrochoerus hydrochaeris): "Passos Nunes" uterine horn ligature. ANIMAL REPRODUCTION, v. 19, n. 2, p. 6-pg., 2022-01-01. (19/03138-0)