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Evaluation of desensibilizing clinical protocols (neural and obliterators) in the management of cervical dentinary hypersensibility

Grant number: 20/03151-3
Support type:Regular Research Grants
Duration: August 01, 2020 - October 31, 2021
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal researcher:Ana Cecília Corrêa Aranha
Grantee:Ana Cecília Corrêa Aranha
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The present study aims to clinically compare the effectiveness of in-office treatments for cervical dentin hypersensitivity (CDH) with different desensitizing proposals (neural protocols and obliterating protocols) through a parallel, randomized, double blind, interventional clinical study. Patients will be evaluated through the inclusion and exclusion criteria. Subjects presenting at least one tooth with a value above 4 on the VAS scale (if more than one sensitive tooth is present, the average VAS values obtained from each lesion per patient will be used) will be randomly allocated to the experimental groups: PART 1 (neural protocol): group 1: control group (placebo, in which the application of a product will be simulated); group 2: Ultra EZ 3% desensitizer (pumice prophylaxis will be performed and then the desensitizing gel will be applied); group 3: AsGaAl laser, (780 nm wavelength under 100mW fixed power relative isolation, 90 J / cm2 energy density, 1J per point at 2 distinct points: cervical and apical), and group 4; irradiation similar to group 3, but in the last session will be applied the desensitizer as described in group 2. All treatments will be performed according to the manufacturer's instructions by a trained researcher. The evaluation of HD will be performed 5 min after the application of the treatments, by a different researcher and also blind to the applied treatment, using the visual analogue pain scale. Volunteers will be called back for HD determination after one week, 1, 3, 6 and 12 months of treatment. In part 2 of the work, in which the obliterating protocols will be evaluated, it will have 4 distinct phases. The clinical phase of this study will evaluate the effects of treatments on patients' pain change, as will Part 1 of this project. Then, the Nd:YAG laser will also be evaluated for temperature increase during irradiation with different protocols, through thermographic analysis, using thermocouples and thermographic camera. Different irradiation protocols and paste use will also be evaluated in a cell culture step. At all stages, the data obtained in the groups and experimental times will be submitted to the appropriate statistical analysis (± = 0.05). (AU)

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