Peptides-polysaccharides conjugates as antimicrobial materials for 3D printing

• Grant number: 19/22671-0
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2020
• End date: September 30, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Agreement: Fonds de la Recherche Scientifique (F.R.S.- FNRS)
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Denise Freitas Siqueira Petri
• Grantee: Denise Freitas Siqueira Petri
• Principal researcher abroad: Amin Shavandi
• Institution abroad: Université Libre de Bruxelles (ULB), Belgium
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Luiz Henrique Catalani ; Michelle da Silva Liberato
• Associated research grant: 18/13492-2 - Synthetic and natural scaffolds applied to regenerative medicine, AP.TEM

Abstract

This joint proposal aims at the creation of new printable peptide-polysaccharide conjugates with antimicrobial properties and the establishment of a fruitful collaboration on biomaterials research. Antimicrobial peptides (AMP) will be isolated from yeast at the Interfaculty School of Bioengineers of University Libré de Bruxelles - ULB, Belgium. The conjugation of AMP with alginate and carboxymethylcellulose acetate butyrate (CMCAB) which will be accomplished by carbodiimide chemistry, at the Institute of Chemistry, University of São Paulo, Brazil. AMP-polysaccharides will be processed using different 3D bioprinting and electrospinning facilities, which are available at both institutions (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ALAVARSE, ALEX CARVALHO; FRACHINI, EMILLI CAROLINE GARCIA; DA SILVA, RAFAEL LEONARDO CRUZ GOMES; LIMA, VITORIA HASHIMOTO; SHAVANDI, AMIN; PETRI, DENISE FREITAS SIQUEIRA. Crosslinkers for polysaccharides and proteins: Synthesis conditions, mechanisms, and crosslinking efficiency, a review. International Journal of Biological Macromolecules, v. 202, p. 39-pg., 2022-01-25. (20/03248-7, 20/01907-3, 19/22671-0, 20/05632-9, 18/13492-2)

ALAVARSE, ALEX C.; MIRZAEI, MAHTA; SHAVANDI, AMIN; PETRI, DENISE F. S.. Improved anti-inflammatory properties of xanthan gum hydrogel physically and chemically modified with yeast derived peptide. Biomedical Materials, v. 18, n. 2, p. 13-pg., 2023-03-01. (18/13492-2, 19/22671-0)

GHAFFARI-BOHLOULI, PEJMAN; ALIMORADI, HOUMAN; PETRI, DENISE FREITAS SIQUEIRA; MOGHASSEMI, SAEID; AMORIM, CHRISTIANI A.; NIE, LEI; SHAVANDI, AMIN. Alleviating hypoxia through self-generating oxygen and hydrogen peroxide fluorinated chitosan: Insights from a kinetic study. CHEMICAL ENGINEERING JOURNAL, v. 473, p. 19-pg., 2023-10-01. (19/22671-0)

MIRZAEI, MAHTA; OKORO, OSEWEUBA VALENTINE; NIE, LEI; PETRI, DENISE FREITAS SIQUEIRA; SHAVANDI, AMIN. Protein-Based 3D Biofabrication of Biomaterials. BIOENGINEERING-BASEL, v. 8, n. 4, APR 2021. (19/22671-0)