Development of ionic liquids-based electroconductive hydrogels

• Grant number: 19/15493-9
• Support type: Regular Research Grants
• Duration: November 01, 2020 - August 31, 2022
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Cooperation agreement: CONFAP - National Council of State Research Support Foundations
• Principal researcher: Valéria de Carvalho Santos Ebinuma
• Grantee: Valéria de Carvalho Santos Ebinuma
• Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Assoc. researchers: Cassamo Ussemane Mussagy ; Fernando Lucas Primo ; Jania Betania Alves da Silva

Abstract

Conventional methods for obtaining electroconductive hydrogels by the incorporation of nanomaterials and conducting polymers present great technical limitations. These are mainly associated with cytotoxicity as well as low solubility, processability and biodegradability. In this project, we propose a strategy for obtaining hydrogels by the functionalization of non-conductive polymers with conductive and non-toxic ionic liquids derived from imidazole and choline. In addition to structurally characterizing hydrogels, we will determine their electroconductive and mechanical properties as well as pore size, degree of swelling and degradation. Additionally, the objective of this project is the biological characterization of these hydrogels, since they can be used in many biomedical applications. Cytotoxic properties, cell adhesion, growth and differentiation will be determined in the presence of hydrogels. Synthesis and molecular characterization of the hydrogels will be done by the team of the RS and the characterization of the electroconductive, mechanical properties, and the determination of pore size, degree of swelling, degradation will be performed by the team of São Paulo. The determination of the biological properties will be determined jointly by the two teams and collaborators. Considering the main objectives of this work, the expected results are classified in results of scientific production, training of human resources, and attendance to the interests of society. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MUSSAGY, CASSAMO U.; SANTOS-EBINUMA, VALERIA C.; HERCULANO, RONDINELLI D.; COUTINHO, JOAO A. P.; PEREIRA, JORGE F. B.; PESSOA JR, ADALBERTO. Ionic liquids or eutectic solvents? Identifying the best solvents for the extraction of astaxanthin and beta-carotene from Phaffia rhodozyma yeast and preparation of biodegradable films. GREEN CHEMISTRY, v. 24, n. 1, NOV 2021. (19/15493-9, 15/11759-3, 18/06908-8, 20/08655-0)

REMONATTO, DANIELA; FERRARI, BARBARA RIBEIRO; BASSAN, JULIANA CRISTINA; MUSSAGY, CASSAMO USSEMANE; SANTOS-EBINUMA, VALERIA DE CARVALHO; DE PAULA, ARIELA VELOSO. Utilization of Clay Materials as Support for Aspergillus japonicus Lipase: An Eco-Friendly Approach. CATALYSTS, v. 11, n. 10, OCT 2021. (19/15493-9, 20/08655-0, 18/06908-8, 20/09592-1, 17/11482-7)

VERISSIMO, NATHALIA VIEIRA; MUSSAGY, CASSAMO USSEMANE; OSHIRO, ARIANE ALVES; NOBREGA MENDONCA, CARLOS MIGUEL; SANTOS-EBINUMA, VALERIA DE CARVALHO; PESSOA JUNIOR, ADALBERTO; DE SOUZA OLIVEIRA, RICARDO PINHEIRO; BRANDAO PEREIRA, JORGE FERNANDO. From green to blue economy: Marine biorefineries for a sustainable ocean-based economy. GREEN CHEMISTRY, v. 23, n. 23, NOV 2021. (18/06908-8, 20/13271-6, 20/14144-8, 19/15493-9, 18/25511-1, 20/08655-0)

MUSSAGY, CASSAMO U.; KURNIA, KIKI A.; DIAS, ANA C. R. V.; RAGHAVAN, VIJAYA; SANTOS-EBINUMA, VALERIA C.; PESSOA JR, ADALBERTO. n eco-friendly approach for the recovery of astaxanthin and 8-carotene from Phaffia rhodozyma biomass using bio-based solvent. Bioresource Technology, v. 345, FEB 2022. (20/08655-0, 19/15493-9, 18/06908-8)

DE OLIVEIRA, FERNANDA; ROCHA, INES L. D.; GOUVEIA ALVES PINTO, DIANA CLAUDIA; VENTURA, SONIA P. M.; DOS SANTOS, ANDRE GONZAGA; CREVELIN, EDUARDO JOSE; SANTOS EBINUMA, VALERIA DE CARVALHO. Identification of azaphilone derivatives of Monascus colorants from Talaromyces amestolkiae and their halochromic properties. Food Chemistry, v. 372, MAR 15 2022. (14/01580-3, 18/06908-8, 19/15493-9)