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Obtaining and validating immunobiologicals for the specific diagnosis and sorotyping of dengue

Grant number: 20/05788-9
Support type:Research Grants - Innovative Research in Small Business - PIPE
Duration: April 01, 2021 - December 31, 2021
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal researcher:Mônica Josiane Rodrigues de Jesus
Grantee:Mônica Josiane Rodrigues de Jesus
Company:Deltalys Biotechnology Produtos Farmacêuticos Ltda
CNAE: Fabricação de preparações farmacêuticas
City: São Paulo
Pesquisadores principais:
Luis Carlos de Souza Ferreira
Associated scholarship(s):21/03695-6 - Obtaining and validating immunobiologicals for the specific diagnosis and sorotyping of Dengue, BP.PIPE

Abstract

Currently, serological tests for antibodies detection that indicate previous infection by the dengue virus (DENV) are compromised by cross-reactivity with Zika virus antigens (ZIKV). In addition, there is no product commercially available products that differentiate DENV types (1 to 4) that patients were previously exposed to. This proposal aims to optimize the methodology for obtaining immunobiologicals (recombinant antigens) applicable to serological diagnosis of DENV, aiming at scaling up their production. Results obtained by a company, a Spin-off of the Biomedical Sciences Institute of USP, demonstrated that the proposal is feasible but requires preparation of the team to respond to national and international market's demands. (AU)

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