Development of polymeric nanoparticles and multifunctional dendrimers for drug delivery

• Grant number: 21/00555-9
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2021
• End date: June 30, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Igor Dias Jurberg
• Grantee: Igor Dias Jurberg
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Nanomedicine is expected to provide solutions to some of modern medicine's unsolved problems and offers new hopes in several critical areas such as cancer treatment, viral and bacterial infections, medical imaging, biosensors, tissue regeneration, and theranostics. The goal of the current project is the development of new biocompatible multifunctional nanomaterials based on polymeric nanoparticles and well-defined multifunctional dendrimers for drug delivery applications. The project will focus on the synthesis of the new materials using innovative synthetic strategies based on orthogonality and click chemistry and their complete physico-chemical characterization. Within this project we are proposing the design of biomaterials with potential activity in the treatment of cancer and diseases caused by inflammation. The cytotoxicity of all the new nanomaterials will be tested against several cell lines in order to define if these materials are valid candidates as drug delivery platforms. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GARZON-PORRAS, ANA M.; BERTUZZI, DIEGO L.; LUCAS, KURT; ORNELAS, CATIA. Well-Defined Bifunctional Dendrimer Bearing 54 Nitric Oxide-Releasing Moieties and 54 Ursodeoxycholic Acid Groups Presenting High Anti-Inflammatory Activity. ACS BIOMATERIALS SCIENCE & ENGINEERING, v. N/A, p. 17-pg., 2022-11-22. (18/02093-0, 15/04929-0, 21/00555-9)

BERTUZZI, DIEGO L.; BRAGA, CAROLYNE B.; PERLI, GABRIEL; ORNELAS, CATIA. Water-Soluble Well-Defined Bifunctional Ferrocenyl Dendrimer with Anti-Cancer Activity. European Journal of Inorganic Chemistry, v. 2022, n. 9, p. 6-pg., 2022-02-01. (17/06146-8, 15/04929-0, 21/00555-9)

BRAGA, CAROLYNE B.; PERLI, GABRIEL; WANG, QI; WYLIE, LUKE; BERTUZZI, DIEGO L.; SOARES, MARCO C. P.; RAMOS, MIGUEL D.; RUIZ, JAIME; PADUA, AGILIO; ASTRUC, DIDIER; et al. Unveiling Hierarchical Self-Assembly of Triazolylferrocenyl Dendrimers: Producing Non-Traditional Intrinsically Green Fluorescent Vesosomes for Nanotheranostics. ADVANCED HEALTHCARE MATERIALS, v. N/A, p. 17-pg., 2024-09-15. (17/24488-3, 17/06146-8, 18/02093-0, 21/00555-9)

PERLI, GABRIEL; BERTUZZI, DIEGO L.; SOUTO, DENIO E. P.; RAMOS, MIGUEL D.; BRAGA, CAROLYNE B.; AGUIAR, SAMILE B.; ORNELAS, CATIA. Synthesis and Characterization of Dendronized Gold Nanoparticles Bearing Charged Peripheral Groups with Antimicrobial Potential. NANOMATERIALS, v. 12, n. 15, p. 15-pg., 2022-08-01. (18/02093-0, 17/06146-8, 15/04929-0, 21/00555-9)

PERLI, GABRIEL; WANG, QI; BRAGA, CAROLYNE B.; BERTUZZI, DIEGO L.; FONTANA, LINIQUER A.; SOARES, MARCO C. P.; RUIZ, JAIME; MEGIATTO, JR., JACKSON D.; ASTRUC, DIDIER; ORNELAS, CATIA. Self-Assembly of a Triazolylferrocenyl Dendrimer in Water Yields Nontraditional Intrinsic Green Fluorescent Vesosomes for Nanotheranostic Applications. Journal of the American Chemical Society, v. 143, n. 33, p. 12948-12954, AUG 25 2021. (18/02093-0, 13/22160-0, 21/00555-9, 17/06146-8)

BERTUZZI, DIEGO L.; MORRIS, MELODY A.; BRAGA, CAROLYNE B.; OLSEN, BRADLEY D.; ORNELAS, CATIA. Synthesis of a Series of Folate-Terminated Dendrimer-b-PNIPAM Diblock Copolymers: Soft Nanoelements That Self-Assemble into Thermo- and pH-Responsive Spherical Nanocompounds. MACROMOLECULES, v. 55, n. 7, p. 16-pg., 2022-04-12. (15/04929-0, 14/50906-9, 21/00555-9)