Analysis of aluminum-zirconia (SNA-Z) nanocomposite scaffolds in bone failures

• Grant number: 20/15700-1
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2021
• End date: March 31, 2024
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Silvio Henrique de Freitas
• Grantee: Silvio Henrique de Freitas
• Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
• City of the host institution: Pirassununga
• Associated researchers: Atanasio Serafim Vidane ; Eliria Maria de Jesus Agnolon Pallone ; Julieta Adriana Ferreira ; Maria Isabel Ribeiro Dias ; Ricardo de Francisco Strefezzi ; Rodrigo Romero Corrêa

Abstract

Orthopedic conditions that require surgical repair using bone tissue replacement are common not only in human medicine, but also in veterinary medicine. This research aims to morphologically analyze the behavior of zirconia alumina nanocomposites scaffolds (SNA-Z) coated with calcium phosphate in induced tibial bone defects on rabbits at different times. The experiment will require 24 New Zealand adult rabbits, randomly divided in 2 Experimental Groups: Group E1 (n: 12), que será subdividido em três subgrupos (E1-30, E1-60 e E1-90): use of SNA-Z coated with calcium phosphate for 7 days in bone failure of the left tibia and Group E2 (n: 12), que será subdividido em três subgrupos (E230, E260 e E290): use of SNA-Z coated with calcium phosphate for 21 days in bone failure of the left tíbia, Control Groups: Negative Control (n: 12), (N-30, N-60 e N-90): bone defect of the right tibia without the use of biomaterial and Positive Control (n: 12), (P-30, P-60 e N-90): use of deproteinized bovine bone in bone failure of the right tíbia. The animals will be evaluated in postoperative immediate, at 30, 60 and 90 days. As a result, SNA-Z incorporation and osseointegration (7 and 21) are expected in induced tibial bone defects on rabbits. (AU)