Multi-user equipment approved in grant 21/06726-0: ion mobility mass spectrometry system (IMS-MS)

• Grant number: 22/00498-8
• Support Opportunities: Multi-user Equipment Program
• Start date: April 01, 2022
• End date: March 31, 2029
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Thiago Carita Correra
• Grantee: Thiago Carita Correra
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 21/06726-0 - Investigation of reactive intermediates in complex chemical and biochemical processes, AP.JP2
• EMU web page: Página do Equipamento Multiusuário não informada
• Type of equipment: Caracterização de Materiais - Espectrometria - De massas
• Manufacturer: Fabricante não informado
• Model: Modelo não informado

Abstract

This proposal aims to expand the scope of the reactive systems evaluated by our research group (organo- and metal-based chiral catalysis) to including more complex reactive systems as polymerization reactions and the formation of drug metabolites and degradation products. To achieve these goals, the infrared ion spectroscopy (IRMPD spectroscopy) technique developed in the framework of the JP1 (2014/15962-5) and the advanced sample methods developed during the FAPESP research project (2019/25634-9) will be applied and enhanced by their synergic use with ion mobility spectrometry (IMS), constituting the state-of-the-art IMS-IRMPD-MS platform for the study of convoluted reaction systems in complex matrices. These techniques would allow the differentiation of isomers in, virtually, any chemical system, enhancing the quality and scope of our research and allowing the access of external users to these state-of-the-art techniques by developing a multiuser instrument as successfully implemented during the JP1 project. This instrumentation will be used to study: i) the first steps of polybenzoxazine formation; ii) the polymerization motifs of polyaniline; iii) the oxidation products of the drug metoprolol and iv) the degradation products of chemotherapy agents cyclophosphamide and ifosfamide. Besides evaluating these relevant chemical species, this project will allow the production of qualified professionals for the mass spectrometry community and the development of a state-of-the-art technique that will be made available for research institutions and the private sectors. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RIBEIRO, FRANCISCO W. M.; SILVA-OLIVEIRA, DANILO; CERVI, GUSTAVO; KOYANAGUI, EDUARDO D.; CORRERA, THIAGO C.. Isomeric Speciation of Bisbenzoxazine Intermediates by Ion Spectroscopy and Ion Mobility Mass Spectrometry. ACS OMEGA, v. 9, n. 39, p. 9-pg., 2024-09-18. (17/18485-1, 21/06726-0, 22/00498-8, 23/01180-4, 23/01070-4, 15/08539-1, 19/16026-5)

RIBEIRO, FRANCISCO W. M.; OMARI, ISAAC; THOMAS, GILIAN T.; PAUL, MATHIAS; WILLIAMS, PETER J. H.; MCINDOE, J. SCOTT; CORRERA, THIAGO C.. Microstructural Analysis of Benzoxazine Cationic Ring-Opening Polymerization Pathways. MACROMOLECULAR RAPID COMMUNICATIONS, v. N/A, p. 7-pg., 2023-10-09. (21/06726-0, 17/18485-1, 23/01180-4, 22/00498-8, 19/25634-9, 19/16026-5, 15/08539-1, 14/15962-5)

RIBEIRO, FRANCISCO W. M.; OMARI, ISAAC; MCINDOE, J. SCOTT; CORRERA, THIAGO C.. Protonation Effects on the Benzoxazine Formation Pathways and Products Distribution. ChemPhysChem, v. 25, n. 19, p. 214-pg., 2024-07-30. (19/25634-9, 17/18485-1, 21/06726-0, 14/15962-5, 22/00498-8, 23/01180-4, 15/08539-1, 19/16026-5)