Use of varied nutrient sources and agro-industrial residues in the production of bacterial cellulose for topical application as a support for sustained release of (metal) antibacterial and antitumor drugs

• Grant number: 21/07458-9
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2022
• End date: April 30, 2024
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Wilton Rogério Lustri
• Grantee: Wilton Rogério Lustri
• Host Institution: Universidade de Araraquara (UNIARA). Associação São Bento de Ensino. Araraquara , SP, Brazil
• Associated researchers: Adriano Marques Gonçalves ; Cristiano Gallina Moreira ; Flávia Aparecida Resende Nogueira ; Hernane da Silva Barud ; Pedro Paulo Corbi

Abstract

Skin and Soft Tissue Infections (SSTI) and Surgical Wound Infections (SWI) are one of the main causes of morbidity worldwide, involving a wide range of etiological agents and multiple pathogenic mechanisms, and may also be mono or polymicrobial. In addition, the skin is an organ prone to the development of cancer, as melanoma, an aggressive form relatively common, which can progress to a metastatic stage, being susceptible to mono or polymicrobial infections that can aggravate the complexity of carcinogenesis and increase patient mortality. Recent research on the development of delivery systems for antibacterial and antitumor drugs, particularly polymeric, highlight the importance of the study in this area. This research has as challenges the search for new metallodrugs with antibacterial activity, inhibitor of ²-lactamases, for association with ²-lactam antibiotics, and with antitumor activity, for incorporation in bacterial cellulose (BC) membranes, produced from sources of diversified nutrients, including agro-industrial residues, applying the circular bioeconomy, aiming at the development of supports for the sustained release of these metallodrugs. Incorporated in CB membranes subjected to chemical modifications, and the performance of in vitro biological studies to determine the antibacterial and inhibitory properties of ²- lactamases, cytotoxic, antiproliferative, as well as studies of possible mechanisms of molecular action, in vitro and by molecular docking, and mutagenic potential and skin permeation tests in Franz cells for safety analysis, aiming to increase the therapeutic arsenal in the topical treatment of SSTI, SWI andskin cancer, which is currently scarce. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LAZARINI, SILMARA C.; YAMADA, CAROLINE; DA NOBREGA, TAINA ROSA; LUSTRI, WILTON ROGERIO. Production of sphere-like bacterial cellulose in cultivation media with different carbon sources: a promising sustained release system of rifampicin. Cellulose, v. 29, n. 11, p. 16-pg., 2022-06-15. (21/07458-9)

PEREIRA, GABRIELE DE MENEZES; NUNES, JULIA H. BORMIO; CRUZ, ALLEFE B.; PEREIRA, DOUGLAS HENRIQUE; BUGLIO, KAIO EDUARDO; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO ERNESTO; FRAJACOMO, SILMARA CRISTINA L.; LUSTRI, WILTON R.; BERGAMINI, FERNANDO R. G.; et al. Synthesis, spectroscopic characterization, antibacterial activity and antiproliferative profile of a new silver(I) complex of 5-fluorocytosine. JOURNAL OF FLUORINE CHEMISTRY, v. 266, p. 9-pg., 2023-02-01. (21/08717-8, 21/07458-9)

LUSTRI, WILTON R.; LAZARINI, SILMARA C.; AQUARONI, NAYARA AP SIMEI; RESENDE, FLAVIA A.; ALEIXO, NADIA A.; PEREIRA, DOUGLAS H.; LUSTRI, BRUNA CARDINALI; MOREIRA, CRISTIANO GALLINA; RIBEIRO, CAMILA M.; PAVAN, FERNANDO R.; et al. A new complex of silver(I) with probenecid: Synthesis, characterization, and studies of antibacterial and extended spectrum beta-lactamases (ESBL) inhibition activities. Journal of Inorganic Biochemistry, v. 243, p. 12-pg., 2023-03-30. (18/00163-0, 19/03049-7, 15/09833-0, 15/20882-3, 18/12062-4, 17/16278-9, 21/07458-9, 17/19243-1, 20/13497-4, 18/12590-0, 19/26696-8, 18/00187-7, 21/08717-8, 18/02344-2)

SILVA, AMANDA A.; FRAJACOMO, SILMARA C. L.; CRUZ, ALLEFE B.; BUGLIO, KAIO EDUARDO; AFFONSO, DANIELE DAIANE; PORTES, MARCELO CECCONI; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO ERNESTO; LUSTRI, WILTON R.; PEREIRA, DOUGLAS H.; et al. Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities. INORGANICS, v. 11, n. 8, p. 21-pg., 2023-08-01. (13/07937-8, 18/12062-4, 21/07458-9, 21/10265-8, 11/01114-4, 14/23950-7, 21/08717-8)