Genetic and ambiental aspects of obesity

• Grant number: 98/15983-8
• Support Opportunities: Research Projects - Thematic Grants
• Start date: December 01, 1999
• End date: February 28, 2005
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Carlos Eduardo Negrão
• Grantee: Carlos Eduardo Negrão
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

In the majority of the industrialized countries, obesity has been characterized as a multifactorial disease that has been associated with many metabolic and cardiovascular disorders. This is the reason why obesity has become an important public health problem that deserves concern.The advance of Epidemiological Genetics and Molecular Biology made it possible to identify the genetic influence in body weight gain or obesity which, in turns, affects caloric intake and energetic consumption.With those concerns in mind, this group of researchers intend to investigate the effect of exercise training and diet on the loss of body weight in obese individuals who have genetic alterations on the B2 adrenergic receptors. In addition, we intend to investigate whether exercise training improves the vasodilatory responses and decreases the sympathetic outflow during mental stress in obese individuals who have genetic alterations on the B2 adrenergic receptors. Finally, we want to study whether exercise training associated with diet reduces 24 hour blood pressure monitoring in those obese individuals with B2 adrenergic receptors alterations. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RIBEIRO, MAURÍCIO M.; SILVA, ALEXANDRE G.; SANTOS, NELSON S.; GUAZZELLE, ISABEL; MATOS, LUCIANA N. J.; TROMBETTA, IVANI C.; HALPERN, ALFREDO; NEGRÃO, CARLOS E.; VILLARES, SANDRA M. F.. Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation, v. 111, n. 15, p. 1915-1923, Apr. 2005. (98/15983-8)

A.C. TONACIO; I.C. TROMBETTA; M.U.P.B. RONDON; L.T. BATALHA; F.H.S. KUNIYOSHI; M.C. LATERZA; P.H. SUZUKI; M.M.G. GOWDAK; A.C.P. BARRETTO; A. HALPERN; et al. Effects of diet and exercise training on neurovascular control during mental stress in obese women. Brazilian Journal of Medical and Biological Research, v. 39, n. 1, p. 53-62, 2006-01-00. (98/15983-8)

SILVA‚ A.G.; RIBEIRO‚ M.M.; TROMBETTA‚ I.C.; NICOLAU‚ C.; FRAZZATTO‚ E.; GUAZZELLI‚ I.; MATOS‚ L.N.J.; HALPERN‚ A.; NEGRO‚ C.E.; VILLARES‚ S.M.F.; et al. Augmented muscle vasodilatory responses in obese children with Glu27 beta (2)-adrenoceptor polymorphism. PEDIATRIC EXERCISE SCIENCE, v. 20, n. 2, p. 157-168, 2008. (98/15983-8)

M.M. RIBEIRO; I.C. TROMBETTA; L.T. BATALHA; M.U.P.B. RONDON; C.L.M. FORJAZ; A.C.P. BARRETTO; S.M.F. VILLARES; C.E. NEGRÃO. Muscle sympathetic nerve activity and hemodynamic alterations in middle-aged obese women. Brazilian Journal of Medical and Biological Research, v. 34, n. 4, p. 475-478, 2001-04-00. (98/15983-8)