| Grant number: | 22/10344-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | December 01, 2022 |
| End date: | November 30, 2025 |
| Field of knowledge: | Health Sciences - Collective Health - Public Health |
| Agreement: | CONFAP - National Council of State Research Support Foundations |
| Principal Investigator: | Ana Maria Moura da Silva |
| Grantee: | Ana Maria Moura da Silva |
| Host Institution: | Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Associated researchers: | Fan Hui Wen ; Felipe Augusto Cerni ; Felipe Gobbi Grazziotin ; Luciana Aparecida Freitas de Sousa ; Manuela Berto Pucca ; Mônica Colombini ; Paulo Sergio Bernarde ; Vincent Louis Viala ; Wuelton Marcelo Monteiro |
| Associated research grant(s): | 24/18009-9 - 1st International Conference on Toxinology in India, AR.EXT |
Abstract
Currently, the northern region of Brazil is the one with the highest incidence and severity of snakebites in the country. Bothrops atrox snake is responsible for the largest number of cases and is found throughout the Amazon, with other species also involved in accidents such as B. brazili, B. taeniatus, B. bilineatus and Bothrocophias hyoprora occurring mainly in Acre and Crotalus durissus ruruima, endemic to Roraima. Despite the high number of accidents, knowledge about the venom of these snakes, human envenomation and the effectiveness of antivenoms in relation to these venoms is still insufficient. Furthermore, despite advances to achieve self-sufficiency in high-quality antivenoms and the expansion of the distribution network, access to treatment is still not available in remote areas of the country, especially in the Amazon. Still in the context of the Amazon region, we have already shown that the severity and mortality of accidents increases considerably due to the great distances by boat traveled by victims to reach the health service. Thus, combined with the lack of knowledge of the venoms of endemic snakes in the region, together with the difficulty of accessing antivenom and health services, an in-depth study of the composition of these venoms and the effectiveness of the serum for poisonings occurring in remote and indigenous communities. In addition to the effectiveness of antivenoms, facilitating access to serotherapy for isolated communities in the Amazon is an urgent obstacle to be resolved. In this way, our project proposes a multidisciplinary study to obtain more knowledge about the composition of the venoms of Amazon snakes, and whether these venoms are recognized by commercial antivenoms, in addition, to propose adjuvant treatments (use of enzyme inhibitors) to complement the serum therapy and validating the protocol for the distribution of antivenoms in remote areas of the Amazon (decentralization). (AU)
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