Functionalized cubosome as bioactive delivery system for oral application

• Grant number: 22/13397-5
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2023
• End date: February 28, 2025
• Field of knowledge: Biological Sciences - Biophysics - Biophysics of Processes and Systems
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Omar Mertins
• Grantee: Omar Mertins
• Principal researcher abroad: Angelina Angelova
• Institution abroad: Université Paris-Sud, Châtenay-Malabry (Paris 11), France
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Patrick Mathews Delgado
• Associated research grant: 21/00971-2 - Crystalline-phase nano cubosome functionalized with biopolymers: development as a drug carrier and in vivo studies in zebrafish (Danio rerio), AP.R

Abstract

Cubosomes are the new generation of liposomes as drug delivery systems especially in applications that require controlled release of encapsulated bioactives such as in the treatment of various types of cancer. The innovative aspect of cubosomes is related to the internal structure of these nanoparticles, a crystalline network where the bilayers formed by lipids are organized in defined topologies forming aqueous labyrinths within a three-dimensional network constituted by the lipid bilayer. Cubosomes functionalized by complex coacervates of biopolymers will be studied regarding their structure for drug and bioactive encapsulation and the interaction with components of the biological application environment will be evaluated in real time. The proposal aims to consolidate and internationalize the research partnership between researchers. (AU)