Advanced search
Start date
Betweenand

Molecular genetics of the hereditary alterations of hemoglobin and functional study of the gamma globin genes

Grant number: 97/11725-1
Support type:Research Projects - Thematic Grants
Duration: July 01, 1998 - August 31, 2003
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Fernando Ferreira Costa
Grantee:Fernando Ferreira Costa
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Co-Principal Investigators:Maria de Fatima Sonati ; Sara Teresinha Olalla Saad ; Valder Roberval Arruda

Abstract

The proposed project comprises the analysis of the molecular alterations in structural variants of hemoglobin, in the hereditary persistence of fetal hemoglobin, and in the thalassemia syndromes; the analysis of polymorphisms of the complex of the beta globin gene in hemoglobinopathies and the functional study and characterization of the transcription factors in the promoters of gamma globin. In addition to this, it will include the cloning of the alpha chain gene of the hemoglobin of the terrestrial tortoise Geochelone carbonaria. It is worth mentioning that the beta globin gene was cloned by us and sequenced. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Genetic pathways 

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DUARTE‚ D.F.; KIMURA‚ E.M.; ALBUQUERQUE‚ D.M.; PINHEIRO‚ V.R.P.; COSTA‚ F.F.; SONATI‚ M.F. Structural Alterations of the $\gamma$-Globin Genes in a Brazilian Population. HEMOGLOBIN, v. 28, n. 1, p. 73-77, 2004.
S.B. JORGE; M.B. MELO; F.F. COSTA; M.F. SONATI. Screening for mutations in human alpha-globin genes by nonradioactive single-strand conformation polymorphism. Brazilian Journal of Medical and Biological Research, v. 36, n. 11, p. 1471-1474, Nov. 2003.
E.M. KIMURA; C.R.E. GRIGNOLI; V.R.P. PINHEIRO; F.F. COSTA; M.F. SONATI. Thalassemia intermedia as a result of heterozygosis for ß0-thalassemia and aaaanti-3.7/aa genotype in a Brazilian patient. Brazilian Journal of Medical and Biological Research, v. 36, n. 6, p. 699-701, Jun. 2003.
CASTILHO‚ L.; RIOS‚ M.; BIANCO‚ C.; PELLEGRINO JR‚ J.; ALBERTO‚ F.L.; SAAD‚ S.T.O.; COSTA‚ F.F. DNA-based typing of blood groups for the management of multiply-transfused sickle cell disease patients. Transfusion, v. 42, n. 2, p. 232-238, 2002.
KIMURA‚ E.M.; JORGE‚ S.B.; OGO‚ S.H.; CESQUINI‚ M.; ALBUQUERQUE‚ D.M.; FATTORI‚ A.; SAAD‚ S.T.O.; COSTA‚ F.F.; SONATI‚ M.F. A NOVEL β-GLOBIN VARIANT: Hb POÇOS DE CALDAS [β 61 (E5) Lys→ Gln]. HEMOGLOBIN, v. 26, n. 4, p. 385-388, 2002.
E. BORGES; M.R.S.C. WENNING; E.M. KIMURA; S.A. GERVÁSIO; F.F. COSTA; M.F. SONATI. High prevalence of alpha-thalassemia among individuals with microcytosis and hypochromia without anemia. Brazilian Journal of Medical and Biological Research, v. 34, n. 6, p. 759-762, Jun. 2001.
M.R.S.C. WENNING; E.M. KIMURA; F.F. COSTA; S.T.O. SAAD; S. GERVÁSIO; S.B. DE JORGE; E. BORGES; N.M. SILVA; M.F. SONATI. alpha-Globin genes: thalassemic and structural alterations in a Brazilian population. Brazilian Journal of Medical and Biological Research, v. 33, n. 9, p. 1041-1045, Set. 2000.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.