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Complex species with potential for application in bio-organics, catalysis, pharmacology and environmental chemistry: conception, preparation, characterization and reactivity

Grant number: 05/60596-8
Support type:Research Projects - Thematic Grants
Duration: June 01, 2006 - November 30, 2010
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Ana Maria da Costa Ferreira
Grantee:Ana Maria da Costa Ferreira
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Denise de Oliveira Silva ; Vera Regina Leopoldo Constantino
Associated scholarship(s):08/54470-0 - Investigation on oxidation and glycoxidation of proteins catalyzed by metal complexes with ligands derived from oxindoles, BP.PD

Abstract

In this project, we intend to improve and expand studies under development in our laboratory, initiated 4 years ago (Process FAPESP No 01/09127-6). Investigations on the structure and reactivity of metal complexes, involving essential metal ions such as iron, copper, zinc, manganese, vanadium or cobalt, as well as heavy metal ions such as ruthenium, free in solution and also inserted in different matrices, have been carried out by 3 research groups, in the area of Inorganic Chemistry, with complementary interests. The main goals for this new period are: 1) design and development of adequate methodologies for the preparation of several coordination compounds with essential and non-essential metal ions, and different ligands, with the aim of obtaining potential metallopharmaceuticals or new catalysts; 2) preparation and utilization of coordination compounds of iron and copper, in solution or inserted in inorganic frameworks, as catalysts for oxidation of pollutants, contaminants and industrial effluents by advanced oxidation processes; 3) preparation of lamellar host structures and their "nanoscroll" derivatives, with the aim of obtaining better catalysts for environmental purposes, or hybrid organic-inorganic materials with peculiar properties; 4) immobilization and/or encapsulating of pharmaceuticals and metallopharmaceuticals, in double lamellar hydroxides, and in natural organic polymers, with the aim of improving their pharmacological activity, decreasing collateral effects, and allowing a controlled release in the organism; 5) physicochemical characterization of the new prepared species, by using more conventional techniques as well as modern ones, specially ESI-MS, XANES, EXAFS and TGA-DSC-MS; 6) evaluation of possible biological activities of the free metallo- and/or immobilized-species prepared, in different processes of biological importance. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Researchers produce artificial compounds with anti-tumor activity 

Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
EFFENBERGER, FERNANDO B.; COUTO, RICARDO A.; KIYOHARA, PEDRO K.; MACHADO, GIOVANNA; MASUNAGA, SUELI H.; JARDIM, RENATO F.; ROSSI, LIANE M. Economically attractive route for the preparation of high quality magnetic nanoparticles by the thermal decomposition of iron(III) acetylacetonate. Nanotechnology, v. 28, n. 11 MAR 17 2017. Web of Science Citations: 13.
MARTINS, DOUGLAS DE J.; HANIF-UR-REHMAN; ALVES RICO, SAMARA R.; COSTA, IGUATINA DE M.; PIO SANTOS, ANDREA C.; SZSZUDLOWSKI, RACHEL G.; SILVA, DENISE DE OLIVEIRA. Interaction of chitosan beads with a copper-naproxen metallodrug. RSC ADVANCES, v. 5, n. 109, p. 90184-90192, 2015. Web of Science Citations: 3.
EFFENBERGER, FERNANDO B.; SULCA, MARCOS A.; TERESA MACHINI, M.; COUTO, RICARDO A.; KIYOHARA, PEDRO K.; MACHADO, GIOVANNA; ROSSI, LIANE M. Copper nanoparticles synthesized by thermal decomposition in liquid phase: the influence of capping ligands on the synthesis and bactericidal activity. JOURNAL OF NANOPARTICLE RESEARCH, v. 16, n. 11 NOV 2014. Web of Science Citations: 10.
MIYAKE, JULIANO ANDREOLI; BENADIBA, MARCEL; RIBEIRO, GEISE; SILVA, DENISE DE OLIVEIRA; COLQUHOUN, ALISON. Novel Ruthenium - Gamma-linolenic Acid Complex Inhibits C6 Rat Glioma Cell Proliferation In Vitro and in the Orthotopic C6 Model In Vivo After Osmotic Pump Infusion. ANTICANCER RESEARCH, v. 34, n. 4, SI, p. 1901-1911, APR 2014. Web of Science Citations: 16.
KABEYA, LUCIANA M.; FUZISSAKI, CAROLINA N.; TALEB-CONTINI, SILVIA H.; FERREIRA, ANA MARIA DA C.; NAAL, ZEKI; SANTOS, EVERTON O. L.; FIGUEIREDO-RINHEL, ANDREA S. G.; AZZOLINI, ANA ELISA C. S.; VERMELHO, ROBERTA B.; MALVEZZI, ALBERTO; DO AMARAL, ANTONIA T.; LOPES, JOAO LUIS C.; LUCISANO-VALIM, YARA MARIA. 7-Hydroxycoumarin modulates the oxidative metabolism, degranulation and microbial killing of human neutrophils. Chemico-Biological Interactions, v. 206, n. 1, p. 63-75, OCT 25 2013. Web of Science Citations: 8.
LIBERATO, MICHELLE S.; KOGIKOSKI, JR., SERGIO; SILVA, EMERSON R.; COUTINHO-NETO, MAURICIO D.; SCOTT, LUIS P. B.; SILVA, RICARDO H.; OLIVEIRA, JR., VANI X.; ANDO, ROMULO A.; ALVES, WENDEL A. Self-Assembly of Arg-Phe Nanostructures via the Solid-Vapor Phase Method. Journal of Physical Chemistry B, v. 117, n. 3, p. 733-740, JAN 24 2013. Web of Science Citations: 15.
SILVA RIBEIRO SANTOS, RODRIGO LUIS; VAN ELDIK, RUDI; SILVA, DENISE DE OLIVEIRA. Kinetic and mechanistic studies on reactions of diruthenium(II,III) with biologically relevant reducing agents. DALTON TRANSACTIONS, v. 42, n. 48, p. 16796-16805, 2013. Web of Science Citations: 11.
SILVEIRA, VIVIAN C.; ABBOTT, MARIANA P.; CAVICCHIOLI, MAURICIO; GONCALVES, MARCOS B.; PETRILLI, HELENA M.; DE REZENDE, LEANDRO; AMARAL, ANTONIA T.; FONSECA, DAVID E. P.; CARAMORI, GIOVANNI F.; DA COSTA FERREIRA, ANA M. Peculiar reactivity of a di-imine copper(II) complex regarding its binding to albumin protein. DALTON TRANSACTIONS, v. 42, n. 18, p. 6386-6396, 2013. Web of Science Citations: 14.
CARAMORI, GIOVANNI F.; PARREIRA, RENATO L. T.; DA COSTA FERREIRA, ANA MARIA. Isatin-Schiff base copper(II) complexes-A DFT study of the metal-ligand bonding situation. International Journal of Quantum Chemistry, v. 112, n. 2, p. 625-646, JAN 15 2012. Web of Science Citations: 10.
DA SILVEIRA, VIVIAN CHAGAS; BENEZRA, HENRI; LUZ, JULIANA SILVA; GEORG, RAPHAELA CASTRO; OLIVEIRA, CARLA COLUMBANO; DA COSTA FERREIRA, ANA MARIA. Binding of oxindole-Schiff base copper(II) complexes to DNA and its modulation by the ligand. Journal of Inorganic Biochemistry, v. 105, n. 12, SI, p. 1692-1703, DEC 2011. Web of Science Citations: 35.
FILOMENI, GIUSEPPE; CARDACI, SIMONE; DA COSTA FERREIRA, ANA MARIA; ROTILIO, GIUSEPPE; CIRIOLO, MARIA ROSA. Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)(2)] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38(MAPK)/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment. Biochemical Journal, v. 437, n. 3, p. 443-453, AUG 1 2011. Web of Science Citations: 30.
ALVES, WENDEL A.; SANT'ANA, ANTONIO C.; ABBOTT, MARIANA P.; HOMEM-DE-MELLO, PAULA; MARTINHO, HERCULANO; SANTOS, REGINA H. A.; FERREIRA, JANAINA G.; TEMPERINI, MARCIA L. A.; PADUAN-FILHO, ARMANDO; DA COSTA FERREIRA, ANA MARIA. Dinuclear Azide-Bridged Copper(II) Complex as Building Block for the Assembly of a 2D-Supramolecular Array. Science of Advanced Materials, v. 2, n. 2, SI, p. 173-183, JUN 2010. Web of Science Citations: 2.
AZZELLINI, M. AMELIA A.; ABBOTT, MARIANA P.; MACHADO, ALESSANDRA; MIRANDA, M. TERESA M.; GARCIA, LEONE C.; CARAMORI, GIOVANNI F.; GONCALVES, MARCOS B.; PETRILLI, HELENA M.; FERREIRA, ANA M. C. Interactions of di-Imine Copper(II) Complexes with Albumin: Competitive Equilibria, Promoted Oxidative Damage and DFT Studies. Journal of the Brazilian Chemical Society, v. 21, n. 7, p. 1303-1317, 2010. Web of Science Citations: 14.
DIAS, PATRICIA M.; KINOUTI, LILIAN; CONSTANTINO, VERA R. L.; FERREIRA, ANA M. D. C.; GONCALVES, MARCOS B.; DO NASCIMENTO, RAFAEL R.; PETRILLI, HELENA M.; CALDAS, MARILIA; FREM, REGINA C. G. SPECTROSCOPIC CHARACTERIZATION OF SCHIFF BASE-COPPER COMPLEXES IMMOBILIZED IN SMECTITE CLAYS. Química Nova, v. 33, n. 10, p. 2135-2142, 2010. Web of Science Citations: 2.
REZENDE, ALEX R.; BIZETO, MARCOS A.; CONSTANTINO, VERA R. L.; HUGUENIN, FRITZ. Lithium Ion Electro-Insertion and Spectroelectrochemical Properties of Films from Hexaniobate. Journal of Physical Chemistry C, v. 113, n. 25, p. 10868-10876, JUN 25 2009. Web of Science Citations: 8.
ALVES, WENDEL A.; MATOS, IORQUIRENE O.; TAKAHASHI, PEDRO M.; BASTOS, ERICK L.; MARTINHO, HERCULANO; FERREIRA, JANAINA G.; SILVA, CLAUDIA C.; DE ALMEIDA SANTOS, REGINA H.; PADUAN-FILHO, ARMANDO; DA COSTA FERREIRA, ANA M. A Chloro-Bridged Linear Chain Imine-Copper(II) Complex and Its Application as an Enzyme-Free Amperometric Biosensor for Hydrogen Peroxide. European Journal of Inorganic Chemistry, n. 15, p. 2219-2228, MAY 2009. Web of Science Citations: 19.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.