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Modulatio of polarized immune responses in immunologically or genetically manipulated animals

Grant number: 99/03778-3
Support type:Research Projects - Thematic Grants
Duration: May 01, 2000 - April 30, 2005
Field of knowledge:Biological Sciences - Immunology
Principal researcher:Momtchilo Russo
Grantee:Momtchilo Russo
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Proper functioning of the immune system depends on cytokines and on cell-to-cell interactions that are mediated by adhesion and co-stimulatory molecules. Cell-to-cell contact is fundamental for lymphocyte activation. However, cytokines are essential for further differentiation of lymphocytes and for the activation of non lymphoid cells such as macrophages. Convincing evidence has accumulated over the past years for the existence of polarized immune responses governed by subsets of CD4+ helper T lymphocytes. It was showed that mouse CD4+ cell clones could be distinguished by their pattern of cytokine secretion. They termed Th1 cells as T cells that produce IL-2, TNF- and the macrophage-activating cytokine (IFN) and Th2 cells as those that produce IL-4, IL-5, IL-6 and IL-13. It soon became clear that Th2-dominated responses were associated with allergic reactions whereas Th1 dominated responses were associated with delayed type hypersensitivity reaction, macrophage activation, and resistance to infection by intracellular parasites. Certainly the Th1/Th2 paradigm is an oversimplification of the complex cellular interactions that operate in the immune system. However it accommodate and synthesize, at least, two major immunological reaction mediated by T cells, namely the delayed-type of hypersensitivity (DTH) and the late phase reaction (LPR) of immediate-type hypersensitivity. Much of our understanding of the molecular mechanisms responsible for Th1 or Th2 polarization came from studies with animals with defined genetic background, or studies that utilized monoclonal antibodies against key cells or cytokines or studies that utilized genetically manipulated animals (KO animals that lack key elements of the immune system). Our proposal is to combine these types of approach to study the following immune reactions that are: 1) dominated by Th2 cells which are associated with generation of allergic responses that occur experimental asthma. We will specially focus on the induction of tolerance (oral or nasal) to asthma; 2) dominated by Th1 cells that are probably involved in macrophage activation induced by microorganisms, lectins and superantigens and in experimental Chagas' disease myocarditis. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA-PINTO‚ F.A.; BASSO‚ A.S.; DE SÁ-ROCHA‚ L.C.; BRITTO‚ L.R.G.; RUSSO‚ M.; PALERMO-NETO‚ J. Neural Correlates of IgE-Mediated Allergy. Annals of the New York Academy of Sciences, v. 1088, n. 1, p. 116-131, 2006.
ALEXANDRE CASTRO KELLER; DUNIA RODRIGUEZ; MOMTCHILO RUSSO. Nitric oxide paradox in asthma. Memórias do Instituto Oswaldo Cruz, v. 100, n. supl. 1, p. 19-23, Mar. 2005.
BASSO, A. S.; BRITTO, L. R. G.; MALUCELLI, B. E.; RUSSO, M.; COSTA-PINTO, F. A. DA. Avoidance behavior and neural correlates of allergen exposure in a murine model of asthma. BRAIN BEHAVIOR AND IMMUNITY, v. 19, n. 1, p. 52-60, Jan. 2005.
MUCIDA‚ D.S.; RODRÍGUEZ‚ D.; KELLER‚ A.C.; GOMES‚ E.; MENEZES‚ J.S.; FARIA‚ ANA; RUSSO‚ M.; OTHERS. Decreased Nasal Tolerance to Allergic Asthma in Mice Fed an Amino Acid-Based Protein-Free Diet. Annals of the New York Academy of Sciences, v. 1029, n. 1, p. 361-365, 2004.

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