New materials and methods applied to (bio) medicine

• Grant number: 05/00157-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: November 01, 2005
• End date: June 30, 2010
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Carlos Frederico de Oliveira Graeff
• Grantee: Carlos Frederico de Oliveira Graeff
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated scholarship(s): 08/06603-0 - Chemical study of conjugated polymers for dosimetry of ionizing radiation, BP.PD

Abstract

In the present proposal three different sensors are developed which are especially useful to physicians as well as to biomedical researchers. In the first, the goal is to make a dosimeter based on the ionizing radiation induced modifications in the electronic properties of conjugated polymers, with special emphasis on poly (piphenilenevinilene). In this sub-project the new dosimeter is proposed to be read using spectrometric techniques and to be used in medical applications such as radiotherapy as well as in the food industry. In the second, a solid state sensor for NO is proposed using an iron-ditiocarbamate complex encapsulated inside a solid matrix with characteristics such as porosity transparency in the UV-VIS and free of electron spin resonance signal. In the third, a miniature dosimeter is developed based on an agglomerate of alanine and a polymer. The mini-dosimeter is intended to be used in small field dosimetry such as: conformal radiotherapy, IMRT, gamma knife, radio surgery with fixed terciary collimators, as well in braquiterapy (small and high dose rates). (AU)

Filed patent(s) as a result of this research project