The role of PPARs in cancer cachexia

• Grant number: 05/01445-0
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2005
• End date: February 29, 2008
• Field of knowledge: Biological Sciences - Biochemistry
• Principal Investigator: Marilia Cerqueira Leite Seelaender
• Grantee: Marilia Cerqueira Leite Seelaender
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Cachexia is closely related to cancer-related morbidity and mortality. Its causes are unknown and there is no therapy able to revert it. Among many symptoms including marked lean and fat mass loss, there is a “metabolic chaos”. Previous studies of our group have shown that hepatic lipid metabolism is greatly affected by the syndrome, aggravating the condition. We intend to investigate whether the alterations in hepatic metabolism are a reflex of cytokine and prostanoid action upon the expression of PPARs, which are nuclear receptors known to regulate many aspects of lipid metabolism (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROSA NETO, JOSE C.; LIRA, FABIO S.; OYAMA, LILA M.; ZANCHI, NELO E.; YAMASHITA, ALEX S.; BATISTA, JR., MIGUEL L.; OLLER DO NASCIMENTO, CLAUDIA M.; SEELAENDER, MARILIA. Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 106, n. 5, p. 697-704, JUL 2009. (05/01445-0)

LIRA, FABIO S.; KOYAMA, CRISTIANE H.; YAMASHITA, ALEX S.; ROSA, JOSE C.; ZANCHI, NELO E.; BATISTA, JR., MIGUEL L.; SEELAENDER, MARILIA C.. Chronic exercise decreases cytokine production in healthy rat skeletal muscle. Cell Biochemistry and Function, v. 27, n. 7, p. 458-461, OCT 2009. (05/01445-0)

BATISTA, JR., M. L.; ROSA, J. C.; LOPES, R. D.; LIRA, F. S.; MARTINS, JR., E.; YAMASHITA, A. S.; BRUM, P. C.; LANCHA, JR., A. H.; LOPES, A. C.; SEELAENDER, M.. Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats. CYTOKINE, v. 49, n. 1, p. 102-108, JAN 2010. (05/01445-0)

SILVERIO, RENATA; LAVIANO, ALESSANDRO; ROSSI FANELLI, FILIPPO; SEELAENDER, MARILIA. L-Carnitine induces recovery of liver lipid metabolism in cancer cachexia. Amino Acids, v. 42, n. 5, p. 1783-1792, MAY 2012. (05/01445-0)

LIRA, FABIO S.; YAMASHITA, ALEX S.; ROSA, JOSE C.; TAVARES, FABIO L.; CAPERUTO, ERICO; CARNEVALI, JR., LUIZ C.; PIMENTEL, GUSTAVO D.; SANTOS, RONALDO V. T.; BATISTA, JR., MIGUEL L.; LAVIANO, ALESSANDRO; et al. Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats. NUTRITION & METABOLISM, v. 8, AUG 24 2011. (05/01445-0)

ROSA, JOSE C.; LIRA, FABIO S.; EGUCHI, RICARDO; PIMENTEL, GUSTAVO D.; VENANCIO, DANIEL P.; CUNHA, CLAUDIO A.; OYAMA, LILA M.; DE MELLO, MARCO T.; SEELAENDER, MARILIA; OLLER DO NASCIMENTO, CLAUDIA M.. Exhaustive Exercise Increases Inflammatory Response via Toll Like Receptor-4 and NF-kappa Bp65 Pathway in Rat Adipose Tissue. Journal of Cellular Physiology, v. 226, n. 6, p. 1604-1607, JUN 2011. (05/01445-0)

YAMASHITA, ALEX SHIMURA; LIRA, FABIO SANTOS; ROSA, JOSE CESAR; PAULINO, ELLENA CHRISTINA; BRUM, PATRICIA CHAKUR; NEGRAO, CARLOS EDUARDO; DOS SANTOS, RONALDO VAGNER; BATISTA, JR., MIGUEL LUIZ; DO NASCIMENTO, CLAUDIA OLLER; OYAMA, LILA MISSAE; et al. Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: The effect of aerobic training and energy restriction. CYTOKINE, v. 52, n. 3, p. 168-174, DEC 2010. (05/01445-0)

LIRA, F. S.; ROSA, J. C.; YAMASHITA, A. S.; KOYAMA, C. H.; BATISTA, JR., M. L.; SEELAENDER, M.. Endurance training induces depot-specific changes in IL-10/TNF-alpha ratio in rat adipose tissue. CYTOKINE, v. 45, n. 2, p. 80-85, FEB 2009. (05/01445-0)