| Grant number: | 06/00779-4 |
| Support type: | Regular Research Grants |
| Duration: | July 01, 2006 - June 30, 2008 |
| Field of knowledge: | Health Sciences - Dentistry - Periodontology |
| Principal researcher: | Márcio Mateus Beloti |
| Grantee: | Márcio Mateus Beloti |
| Home Institution: | Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
Abstract
Guided tissue regeneration (GTR) is a technique that uses a barrier membrane, which can allow the repopulation of local sites by their own cells. The aim of this project is investigated the in vitro biocompatibility of a novel membrane of the composite poly(vinylidene-trifluoroethytele)/barium titanate (P(VDF-TrFE)/BT). Osteoblasts, fibroblasts and keratinocytes, cells that will be in contact with the membrane during GTR, will be cultivated on P(VDF-TrFE)/BT and e-PTFE (control) membranes and the following parameters will be evaluated: cell adhesion, proliferation, and viability, apoptosis, total protein content, collagen content, alkaline phosphatase (ALP) activity, and bone-like nodule formation for cultures of osteoblasts and fibroblasts; cell adhesion, proliferation, viability, and apoptosis for keratinocytes culture. (AU)
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