Physiological consequences of different ingestion levels of iron and calcium and their interaction with phytates and fructans: study in rats

• Grant number: 06/01735-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2006
• End date: October 31, 2008
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Célia Colli
• Grantee: Célia Colli
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The mandatory fortification of wheat and corn flour with Fe and folic acid was an important achievement for the reduction of the prevalence of iron deficiency anemia in Brazil. However, as a background for the evaluation of the impact of this program the possibilities of Fe overload and its consequences should be evaluated and those factors that improve Fe bioavailability should be focused under another perspective. Diet components as phytates that lower the mineral bioavailability can be useful when iron overload is concerned. Some physiological alterations are result of Fe deficiency and Fe overload as well, and may affect lipid and bone metabolism and the gastrointestinal tract. The ingestion of fructans has been associated to local and sistemic positive effects in the mineral bioavailability and lipid metabolism. Assuming that the Fe and Ca nutriture should not be evaluated alone and that physiological and nutritional factors may interfere in their absorption, transport and storage the aim of this study is to evaluate the physiological consequences of different levels of Fe and Ca intake and the effects of their interactions with phytates and/or fructans in rats. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COCATO, MARIA LUCIA; LOBO, ALEXANDRE RODRIGUES; AZEVEDO-MARTINS, ANNA KARENINA; FILHO, JORGE MANCINI; MARQUES DE SA, LILIAN ROSE; COLLI, CELIA. Effects of a moderate iron overload and its interaction with yacon flour, and/or phytate, in the diet on liver antioxidant enzymes and hepatocyte apoptosis in rats. Food Chemistry, v. 285, p. 171-179, JUL 1 2019. (06/01735-0)

LOBO, ALEXANDRE RODRIGUES; COCATO, MARIA LUCIA; BORELLI, PRIMAVERA; GAIEVSKI, EDUARDO H. S.; CRISMA, AMANDA R.; NAKAJIMA, KARINA; NAKANO, EDUARDO Y.; COLLI, CELIA. Iron bioavailability from ferric pyrophosphate in rats fed with fructan-containing yacon (Smallanthus sonchifolius) flour. Food Chemistry, v. 126, n. 3, p. 885-891, JUN 1 2011. (06/01735-0)

LOBO, ALEXANDRE RODRIGUES; SZPAK GAIEVSKI, EDUARDO HENRIQUE; COLLI, CELIA. Hemoglobin Regeneration Efficiency in Anemic Rats: Effects on Bone Mineral Composition and Biomechanical Properties. BIOLOGICAL TRACE ELEMENT RESEARCH, v. 143, n. 1, p. 403-411, OCT 2011. (06/01735-0)

LOBO, ALEXANDRE RODRIGUES; COCATO, MARIA LUCIA; MARQUES DE SA, LILIAN ROSE; COLLI, CELIA. Dietary Iron Overload: Short- and Long-Term Effects on Cecal Morphometry in Growing Rats. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, v. 60, n. 6, p. 397-402, DEC 2014. (06/01735-0)

LOBO, ALEXANDRE R.; COCATO, MARIA LUCIA; JORGETTI, VANDA; DE SA, LILIAN R. M.; NAKANO, EDUARDO Y.; COLLI, CELIA. Changes in bone mass, biomechanical properties, and microarchitecture of calcium- and iron-deficient rats fed diets supplemented with inulin-type fructans. Nutrition Research, v. 29, n. 12, p. 873-881, DEC 2009. (06/01735-0)