Vascular reactivity in rat pulmonary arteries and mesenteric after pulmonary ischemia/reperfusion: effect of the physical training

• Grant number: 06/07134-9
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2007
• End date: June 30, 2009
• Field of knowledge: Biological Sciences - Pharmacology - General Pharmacology
• Principal Investigator: Angelina Zanesco
• Grantee: Angelina Zanesco
• Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil

Abstract

The systems cardiovascular and respiratory play an important role in the homeostasis of the organism, either in resting or exercise conditions. The respiratory system is the responsible for the gaseous exchanges, thus supplying oxygen to the tissues and removing carbon dioxide. Moreover, endothelial cells, present in the lung, play an important role in the synthesis and metabolism of a variety of substances. Postoperative pulmonary injury represents one of the most frequent complications after surgery procedures and is the main causes of death in the western world. A number of studies have been showed that ischemia/reperfusion process produces serious endothelial damage. It has been documented that the main causes of this endothelium lesions is due to the reperfusion leading to release of inflammatory cytokines. Physical training has been used as a non pharmacological tool to prevent or to treat cardiovascular disease. However, the effect of the physical training on the pulmonary functions after ischemia/reperfusion has not been investigated. Furthermore, no studies exist to investigate if exercise training can prevent or reduce the endothelial injuries caused by pulmonary ischemeia/reperfusion process. Therefore, the objective of this work will be to evaluate the vascular reactivity of the mesenteric and pulmonary artery after pulmonary ischemia/reperfusion process and the effect of the physical training for 8 weeks on this response. Additionally, circulating factors such as IL-6 and the expression and activity of nitric oxide synthase and superoxide dismutase (SOD) will be analysed. (AU)