Histaminergic system influence on emocional learning in mice submitted to the elevated cross maze

• Grant number: 07/03822-0
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2007
• End date: November 30, 2009
• Field of knowledge: Humanities - Psychology - Physiological Psychology
• Principal Investigator: Rosana Mattioli
• Grantee: Rosana Mattioli
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

The Neuroscience Laboratory of the Federal University of S. Carlos has carried through some research with contradictory results on the performance of the histaminergic system in the learning processes and memory in fish. Recently, Faganello and Mattioli (2006) studied the effect of the CPA in fish after telencephalic ablation, using an associative task with food. In this study they verified that the animals with injury and that did not receive CPA nor saline, they had presented slower acquisition of the task. However the ablated animals injected with saline learned the task, whereas the injected ones with CPA behaved as the not injected ones. These data suggest that the possible the existence of amnesic action or an ansiolitic action of the histamine, also indicating a probability that these effects occur thought the modulation of some component of the emotional learning. The aim of the present study will be to investigate the participation of the histaminergic system in learning processes and emotional memory in mice through peripheral injections and intra-amygdala injections of histamine and its antagonists.For these purposes we will use the paradigm of exposition and re-exposition of mice to the Elevated Plus Maze (EPM) in different situations: 1. after histamine injections and its different antagonists, to evaluate the effects of this system in the acquisition of emotional learning; 2. Tests of injections after EPM exposition of agonists and histaminergic antagonists, to evaluate retention and 3. Central blockade of the systemic injection results through central injections of the antagonists H1, H2 and H3 in the amygdala. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SERAFIM, K. R.; KISHI, M.; CANTO-DE-SOUZA, A.; MATTIOLI, R.. L-histidine provokes a state-dependent memory retrieval deficit in mice re-exposed to the elevated plus-maze. Brazilian Journal of Medical and Biological Research, v. 43, n. 1, p. 100-106, JAN 2010. (07/03822-0)